ABSTRACT
Our study of 28 carefully selected patients proved that ofloxacin is a safe and effective drug for mild to moderately severe community-acquired pneumonia. An effective oral antimicrobial drug such as ofloxacin can be used as an alternative to conventional therapy in community-acquired pneumonia.
Subject(s)
Administration, Oral , Adolescent , Adult , Aged , Bacterial Infections/complications , Female , Humans , Male , Microbial Sensitivity Tests , Middle Aged , Ofloxacin/administration & dosage , Pneumonia/drug therapy , Sputum/microbiologyABSTRACT
An open study was carried out on 22 individuals with a moderate degree of assess the prophylactic efficacy and tolerance of Zingiber cassumunar Roxb. The group consisted of 8 men and 16 women, aged 19-64 years (mean age 44.1 years). After six weeks of basal assessment, all subjects received oral Zingiber cassumunar Roxb, at a dosage of 500 mg. per day for body weight of 50 kg. or under, 750 mg. per day for body weight between 50-55 kg. and 1,000 mg. if over 55 kg. The drug was given orally twice daily for 16 weeks. Examination of the patients was made before starting the treatment and after on the 2nd, 4th, 6th, 10th, 14th, 18th, 22nd week, respectively. Monitoring of the following parameters was performed: patient’s symptoms, ventilatory function, and consumption of antiasthmatic drugs. Zingiber cassumunar Roxb, was found to provide a significant protection against asthmatic attacks in 19 out of 22 cases (86.4%). Statistically significant reduction in asthmatic symptoms as well as the reduction in the use of bronchodilators and steroids were noted between 1-3 and 2-4 months after treatment respectively. Statistically significant improvement in peak expiratory flow rate and FEV1 were also noted in the second month of treatment. Slightly increased frequency in bowel movement was noted in 5 patients and one patient complained of mild headache.
Subject(s)
Adolescent , Adrenergic beta-Agonists/pharmacology , Adult , Albuterol/pharmacology , Asthma/drug therapy , Cardiovascular System/drug effects , Clinical Trials as Topic , Double-Blind Method , Ethanolamines/pharmacology , Female , Hemodynamics/drug effects , Humans , Male , Middle Aged , Procaterol , Random Allocation , Respiratory Function TestsSubject(s)
Adolescent , Adult , Antibodies, Antinuclear/immunology , Autoantibodies/immunology , Child , Female , Fluorescent Antibody Technique , Humans , Male , Middle Aged , ThailandABSTRACT
Blood gas analysis of arterial blood was performed in 34 patients with beta o-thalassaemia/haemoglobin E disease and homozygous beta o-thalassaemia. Among the 22 splenectomised patients 19 had PaO2 lower than the normal expected value, and 18 of these had PaO2 lower than 80 mmHg. Of the 12 non-splenectomised patients 5 had PaO2 lower than the expected normal value but only in one case it was lower than 80 mmHg. After aspirin or Persantin administration there was a definite rise in the PaO2 in 10 out of 12 patients. The hypoxaemia is believed to occur from increased platelet aggregation leading to pulmonary artery occlusion. The rise of the arterial PaO2 after aspirin administration indicates that the observed hypoxaemia is due to reversible platelet aggregation in the majority of cases.