Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add filters








Language
Year range
1.
International Journal of Traditional Chinese Medicine ; (6): 842-846, 2020.
Article in Chinese | WPRIM | ID: wpr-863686

ABSTRACT

Objective:To evaluate the clinical efficacy of modified Baihe-Gujin Decoction combined with routine chemotherapy for the elderly patients with primary treated pulmonary tuberculosis and lung-kidney yin deficiency. Methods:A total of 94 patients who met the inclusion criteria in our hospital from January 2016 to January 2018 were selected and divided into 2 groups according to the random number table method, with 47 patients in each group. The control group was treated with the routine chemotherapy regimen of 2HRZE/4HR (H: isoniazid, R: rifampicin, Z: pyrazinamide, E: ethambutanol), the observation group was treated with Baihe-Gujin Decoction on the basis of the routine chemotherapy. Both groups were treated continuously for 6 months. The sputum negative rate was observed 2, 5 and 6 months after treatment, The closure of cavity shadows was observed by chest CT. The content of IL-6 and IFN-γ-inducible protein-10 were detected by double antibody sandwich ELISA. T cell subsets was detected by flow cytometry. And the clinical efficacy was evaluated. Results:The total effective rate was 87.2% (41/47) in the observation group and 61.7% (29/47) in the control group, and the difference between the two groups was statistically significant ( χ2=8.050, P=0.004). After treatment, the TCM syndrome score of the observation group was significantly lower than that of the control group ( t=5.698, P<0.01). At the end of 6 months after treatment, the sputum negative rate in the observation group was significantly higher than that of the control group ( t=5.317, P=0.021), the effective rate of cavity shadow closure (95.7% with 45/47 vs. 83.0% with 39/47) in the observation group was significantly higher than that of the control group ( χ2=4.029, P=0.044). After treatment, the levels of CD3 +, CD4 + and CD4 +/CD8 + in the observation group were all significantly higher than those in the control group ( t values were 2.107, 3.571 and 2.351, respectively, all Ps<0.05), and the levels of CD8 + in the observation group were all significantly lower than those in the control group ( t=2.711, P=0.005). The levels of IL-6 and IFN-γ-induced protein-10 in the observation group were significantly lower than those in the control group ( t values were 2.517 and 2.890, respectively, all Ps<0.05). Conclusions:The modified Baihe-Gujin Decoction combined with routine chemotherapy can improve the immunity of the elderly patients with primary treated pulmonary tuberculosis with lung-kidney yin deficiency, and improve the clinical efficacy.

SELECTION OF CITATIONS
SEARCH DETAIL