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OBJECTIVE@#This study aimed to investigate the potential relationship between urinary metals copper (Cu), arsenic (As), strontium (Sr), barium (Ba), iron (Fe), lead (Pb) and manganese (Mn) and grip strength.@*METHODS@#We used linear regression models, quantile g-computation and Bayesian kernel machine regression (BKMR) to assess the relationship between metals and grip strength.@*RESULTS@#In the multimetal linear regression, Cu (β = -2.119), As (β = -1.318), Sr (β = -2.480), Ba (β = 0.781), Fe (β = 1.130) and Mn (β = -0.404) were significantly correlated with grip strength ( P < 0.05). The results of the quantile g-computation showed that the risk of occurrence of grip strength reduction was -1.007 (95% confidence interval: -1.362, -0.652; P < 0.001) when each quartile of the mixture of the seven metals was increased. Bayesian kernel function regression model analysis showed that mixtures of the seven metals had a negative overall effect on grip strength, with Cu, As and Sr being negatively associated with grip strength levels. In the total population, potential interactions were observed between As and Mn and between Cu and Mn ( P interactions of 0.003 and 0.018, respectively).@*CONCLUSION@#In summary, this study suggests that combined exposure to metal mixtures is negatively associated with grip strength. Cu, Sr and As were negatively correlated with grip strength levels, and there were potential interactions between As and Mn and between Cu and Mn.
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Cross-Sectional Studies , Bayes Theorem , China/epidemiology , Metals/toxicity , Arsenic , StrontiumABSTRACT
Objective:To investigate the clinical efficacy of hip arthroscopy in the treatment of acetabular labral injury combined with cysts.Methods:A total of 14 patients (5 males and 9 females) aged 35.46±12.62 years (range, 26-57 years) with acetabular labral injury complicated with cyst who underwent hip arthroscopy in Department of Sports Injury and Arthroscopy, Tianjin Hospital from January 2017 to April 2022 were retrospectively analyzed. There were 8 cases of left hip and 6 cases of right hip with an average body mass index of 24.35±3.14 kg/m 2 (range, 20.2-28.4 kg/m 2). The duration of symptoms was 6.25±4.39 months (range, 3-11 months). All patients underwent hip arthroscopic cyst cleaning and glenoid labral suturing. The femoral neck α angle, lateral center rim angle, visual analogue score (VAS), Harris hip score (HHS), and international hip outcome tool scores (iHOT-12) were compared before and after operation. Results:All patients successfully completed the operation and were followed up for 10.23±2.45 months (range, 1.5-18 months). The difference between the patients' hip VAS before and after operation was statistically significant ( F=108.47, P<0.001). The VAS score at 18 months after operation was 1.34±0.83, which was significantly lower than that before operation 7.85±1.12 and at 6 weeks after operation 5.03±1.60 ( P<0.05). The difference between the patients' hip HHS scores before and after operation was statistically significant ( F=96.89, P<0.001). The HHS score at 18 months after operation was 85.58±4.65, which was significantly higher than that before operation 54.36±2.31 and 6 weeks after operation 61.12±1.20 ( P<0.05). The differences of iHOT-12 scores before and after operation were statistically significant ( F=117.92, P<0.001). The iHOT-12 score of 18 months after operation was 78.36±2.28 points, which was higher than that before operation 31.39±5.21 points and 6 weeks after operation 47.88±2.20 points, and the difference was statistically significant ( P<0.05). The difference of α angle of femoral neck before and after operation was statistically significant ( F=101.56, P<0.001). The α angle of femoral neck at 12 months after operation was 45.32°±3.16°, which was significantly lower than that before operation 50.86°±8.41° ( P<0.05). The difference of lateral center rim angle before and after operation was statistically significant ( F=100.38, P<0.001). The lateral center rim angle was 28.23°±5.32° at 12 months after operation, which was smaller than that before operation 32.16°±5.13°, and the difference was statistically significant ( P<0.05). Conclusion:Hip arthroscopy in the treatment of acetabular labral injury with cysts can relieve hip pain and improve hip function.
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Objective@#To conduct a comparative study on the specific effects of systematic sex education on adolescent students in terms of sexual cognition, sexual values, and sexual adaptation, and to provide the support for conducting a comprehensive education in middle schools.@*Methods@#A whole group sampling method was used to select 3 369 middle and high school students from six general and vocational middle schools in Sichuan Province, which were divided into systematic sex education schools and non systematic sex education schools, and a comparative study was conducted using the Adolescent Mental Health Scale.@*Results@#The results showed that the adolescent students who received systematic sex education were significantly different from those who did not receive systematic sex education in terms of sex related cognition (7.18±6.24, 5.65±7.40), sexual values(7.60±1.17，7.30±1.24), and sexual adjustment (11.49±1.29，11.10±1.41). All differed significantly ( t =5.95, 6.80,7.57, P <0.01). The students who received systematic education in junior middle school were higher than those who received non systematic education in sex related cognition, sexual values and sexual adaptation ( P <0.01). However, in senior high school, the differences in systematic education are only shown in sexual values control and self adaptation in sexual adjustment ( P <0.01). There were significant differences in sex related cognition, sexual values and sexual adjustment between male and female students who received systematic education and non systematic education ( P <0.01).@*Conclusion@#Systematic sex education is more beneficial to the psychosexual health of adolescent students than non systematic sex education in schools.
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Soil microbes are the important indicator of soil quality. For exploring Chuanminshen violaceum planting to microbial effects in tobacco soil, this paper adopted Illumina MiSeq high-throughput sequencing to research the change of bacteria and fungi at the phylum and genus in the soil. The results showed that the Ch. violaceum planting increased the biodiversity of bacteria and fungi. The influence on fungi was greater than that on bacteria. It greatly increased the sequence of fungi, it obtained 32 978 16S rDNA and 32 229 18S rDNA sequence number. There was no change of the top three phylums in bacteria, but the content changed, Proteobacteria and Acidobacteria reduced by 1.73% and 1.4% respectively, and Actinobacteria increased by 0.65%. The advantage phylum Ascomycete in tobacco reduced by 27.99% to be second advantage phylum after Ch. violaceum planting, and the second advantage phylum Basidiomycete increased by 23.69% to become the first dominant fungi. At the genus, Ch. violaceum planting changed the order of dominant genus and the abundance was also changed. Some changed largely such as uncultured Acidobacteriaceae Subgroup-1, Gemmatimonas, Subgroup-2,uncultured Nitrosomonadaceae for bacteria, norank Sordariales, norank Agaricomycetes, Phialophora for fungi. Especially the rotation increased antagonistic microbes and physiological microbes and decreased pathogenic microbes. So the Ch. violaceum planting can improve the microbe community in tobacco soil.
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ObjectiveTo observe the clinical curative effect of applying large dose of raw rhubarb and mirabilite for treatment of patients with acute pancreatitis (AP).Methods A prospective study was conducted; 63 hospitalized patients with AP accompanied by bowel repletion heat bind syndrome identified by Traditional Chinese Medicine (TCM) differentiation method admitted to Sichuan Province Forestry Center Hospital from January 2012 to June 2015 were enrolled, and they were divided into an observation group (32 cases) and a control group (31 cases) according to random number table method. The two groups received western conventional treatment, additionally the control group applied Dachengqi decoction and Qingyi decoction with addition and subtraction of herbs according to the patient's individual situation (ingredients: radix bupleuri 15 g, radix paeoniae alba 15 g, the raw rhubarb (after) 15 g, radix scutellariae 9 g, rhizoma coptidis 9 g, radix aucklandiae 10 g, corydalis 15 g, mirabilite 9 g (a blunt), aurantii fructus immaurus 15 g, magnolia officinalis 15 g), while in the observation group, on the basis of treatment in the control group, additionally, a large dose of raw rhubarb 30 g decocted at last in the decoction and mirabilite 30 g in a large amount of drinking water were taken, 360 mL decoction was prepared for each one of the two groups, 120 mL per 8 hours was injected via a gastric tube, and after the injection of drug, the tube was closed for 1 hour. No adverse reactions were seen, and after the recovery of intestinal function, the method of taking decoction was changed to oral administration. When the daily defecation was above 3 times, the dose should be reduced, and more than five times, the drug should be withdrawn. The abdominal pain, abdominal distension relief time, blood amylase recovery to normal time, peritoneal irritation disappearance time, ventilation and defecation time, length of stay in hospital, cost of hospitalization, incidence of adverse reaction (abdominal pain), complications disappearance time and prognosis were observed in two groups.Results The abdominal pain and abdominal distension relief time (hours: 30.2±12.1 vs. 41.1±15.1), blood amylase recovery to normal time (hours:121±38 vs. 180±56), peritoneal irritation disappearance time (hours: 31.1±25.2 vs. 43.6±21.2), intestinal ventilation and defecation time (hours: 31.5±25.5 vs. 43.3±26.2), length of stay in hospital (days: 20.5±3.2 vs. 25.6±3.9), complications disappearance time (days:7.6±2.9 vs. 11.5±3.1) were significantly shortened in observation group than those in control group (allP 0.05).Conclusion The therapeutic effect of integrated conventional western medicine and dachengqi decoction and qingyi decoction with addition of a large dose of rhubarb and mirabilite for treatment of patients with acute pancreatitis is significantly better than that of using conventional dose of the above treatment without the addition.
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Objective:To investigate cerebral angiography Features of patients with ischemic cerebrovascular disease.Methods:One hundred and twenty seven patients with ischemic cerebrovascular disease were selected in our hospital from March 2013 to April 2015, statistical analysis of their cerebral angiography differences at different ages, different types of ischemic cerebrovascular disease.Results: One hundred and twenty seven patients were found 97 patients(76.4%) had cerebral artery occlusion or stenosis, simple intracranial stenosis 40 cases, 31 cases of simple extracranial stenosis, 26 intracranial and extracranial stenosis cases; on the view of age, young patients with simple intracranial stenosis (69.2%), while the proportion of elderly patients in intracranial and extracranial stenosis was 40.5%, significantly higher than the proportion of old and middle-aged patients; patients with ischemic cerebrovascular disease at different types of stenosis and stenosis had no significant difference.Conclusion: Patients with ischemic cerebrovascular disease in different age have different distribution and different stenosis, especially in the largest proportion of young patients with occlusion, while parts of the brain in patients with vascular stenosis and stenosis and ischemic cerebrovascular disease the type was no significant association.
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<p><b>OBJECTIVE</b>To investigate the expression of aquaporin (AQP)-1, 3, 8, 9 in human fetal membrane and their role in the human amniotic fluid circulation.</p><p><b>METHODS</b>RT-PCR was employed for detection of the expressions of AQP-1, 3, 8, 9 mRNA in human amnion and chorion from 20 women with normal term pregnancy.</p><p><b>RESULTS</b>AQP-1, 3, 8, 9 mRNA expression was detected in both human amnion and chorion, and no significant difference was found in their expression levels or between the amnion and chorion (P>0.05).</p><p><b>CONCLUSION</b>AQP-1, 3, 8, 9 can be associated with intramembranous transport and volume regulation of amniotic fluid.</p>