Research Progress on Risk Factors of Brain Metastasis in Non-small Cell Lung Cancer / 中国肺癌杂志

Brain metastasis of non-small cell lung cancer (NSCLC) is a common treatment failure mode, and the median survival time of NSCLC patients with brain metastasis is only 1 mon-2 mon. Prophylactic cranial irradiation (PCI) can delay the occurrence of brain metastasis, but the survival benefits of NSCLC patients are still controversial. It is particularly important to identify the patients who are most likely to benefit from PCI. This article reviews the high risk factors of brain metastasis in NSCLC.
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Establishment and identification of C57BL/6 mouse model with radiation-induced pulmonary fibrosis / 中华放射肿瘤学杂志

Objective:To establish the mouse model with radiation-induced pulmonary fibrosis, and to identify and analyze it from the aspects of function, imaging and pathology.Methods:Thirty C57BL/6 mice were randomly divided into the control group, 16 Gy irradiation group and 20Gy irradiation group. The mice in the irradiation groups received a single 16 Gy or 20 Gy chest X-ray irradiation, and underwent functional examination, imaging examination and pathological examination at 3 and 6 months after irradiation.Results:At 6 months after irradiation, hair on the chest and back of the mice turned white and fell off, and the airway resistance was increased significantly. CT images showed extensive patch shadows and consolidation in the lung. Three dimensional reconstruction suggested that the lung of mice was distorted and deformed, and the volume was decreased significantly. Pathological examination confirmed that there was extensive pulmonary fibrosis.Conclusions:Significant pulmonary fibrosis occurs after 6 months of chest irradiation in mice. The animal model of radiation-induced pulmonary fibrosis in C57BL/6 mice was successfully established.

Active surveillance and response evaluation strategy after neoadjuvant therapy for esophageal cancer / 中华放射肿瘤学杂志

A considerable proportion of esophageal carcinoma patients could achieve pathological complete response (pCR) after neoadjuvant therapy, for whom accurate response evaluation and active surveillance rather than surgery-aiming to avoid the complications, mortality and reduced quality of life after surgery-has become a research hotspot. To detect residual disease and predict pCR accurately by appropriate method(s) is the key of active surveillance strategy. In this article, we elaborated the active surveillance strategy of esophageal cancer and characteristics of different evaluation methods in terms of radiology, pathology and combined detection.

Consensus and disputes on the adjuvant therapy for non-small cell lung cancer with positive surgical margins / 中华放射肿瘤学杂志

For non-small cell lung cancer (NSCLC) patients with positive surgical margins, the survival rates can be dramatically decreased. However, high-level evidence is lacking in the standard adjuvant treatment for NSCLC patients with positive surgical margins. In this article, consensus and disputes on the adjuvant therapy for NSCLC patients with positive surgical margins were reviewed.

Research progress onneoadjuvant therapy in stage ⅢA-N2 non-small cell lung cancer / 中华放射肿瘤学杂志

Ⅲ A-N2 NSCLC is a group of heterogeneous diseases.The optimal treatment modality remains controversial.How to choose suitable neoadjuvant treatment modalities including chemotherapy,radiotherapy,target therapy and immunotherapy remains unclear.In this article,research progress on neoadjuvant therapy of NSCLC was reviewed to evaluate the efficacy and safety for different modalities.

Research progress onneoadjuvant therapy in stage ⅢA-N2 non-small cell lung cancer / 中华放射肿瘤学杂志

ⅢA-N2 NSCLC is a group of heterogeneous diseases. The optimal treatment modality remains controversial. How to choose suitable neoadjuvant treatment modalities including chemotherapy, radiotherapy, target therapy and immunotherapy remains unclear. In this article, research progress on neoadjuvant therapy of NSCLC was reviewed to evaluate the efficacy and safety for different modalities.

Progress in adjuvant therapy decision-making after endoscopic resection of early esophageal cancer / 中华放射肿瘤学杂志

Both endoscopic resection and surgery are the common treatment modes for early esophageal cancer. Compared with radical surgery, endoscopic resection has the advantages of less trauma, quicker recovery, lower cost, less complications, the preservation of the normal anatomy, the physiological function of the esophagus, and higher postoperative quality of life. For patients with a high risk of lymph node metastasis, endoscopic resection alone can lead to inadequate treatment, which need adjuvant therapies. Currently, the common adjuvant therapies consist of adjuvant radiochemotherapy and adjuvant radiochemotherapy combined with surgery. How to combine endoscopic resection with adjuvant therapy to bring maximal benefits to patients has become the hot topic in the field of clinical researches. In this article, the current research status, progress and challenges in the combination of endoscopic resection and adjuvant therapy for the treatment of high-risk patients were reviewed.

Application mechanisms of radiotherapy combined with immune checkpoint inhibitors / 中华放射肿瘤学杂志

Remarkable advances have been made in immunotherapy,especially immune checkpoint inhibitors.However,only less than 30％ patients would respond to single checkpoint inhibitors.Radiotherapy can augment the anti-tumor immune responses elicited by immunotherapy,either by way of synergy or complementation.This article reviews the mechanisms,the advances and challenges in combination therapy.

Research progress in radiotherapy combined with immunotherapy for non-small cell lung cancer / 中华放射肿瘤学杂志

Radiotherapy is the common traditional treatment for non-small cell lung cancer (NSCLC).In recent years,remarkable advances have been made in immunotherapy,especially the use of immune checkpoint inhibitors.How to effectively combine radiotherapy and immunotherapy to maximize the benefit for patients has become a hot topic in clinical research.This article expounds recent research progress in immunotherapy for NSCLC,the effect of radiotherapy on tumor immunology,and the advances and challenges in radiotherapy combined with immunotherapy for NSCLC.

Clinicopathological characteristics, diagnosis and treatment of combined small cell lung cancer / 国际肿瘤学杂志

Combined small cell lung cancer (C-SCLC) is a special subtype of small cell lung cancer (SCLC),which has a low incidence and diagnostic rate.However,the incidence and diagnostic rate appear an increasing tendency recently.The clinical features of C-SCLC are similar to the pure SCLC,while it has a relatively limited stage.The main treatment pattern of C-SCLC is multimodality therapy,though the response to chemotherapy in C-SCLC is relatively poor.Survival between patients with C-SCLC versus SCLC is similar.KPS,stage,composite components,tumor location and diameter,surgery margin are prognostic factors.Radiotherapy can benefit for the patients with ⅢA/ⅢB disease,positive lymph nodes,or with more metastatic lymph nodes after surgery.

Attention networks in patients with Parkinson' s disease / 中华神经科杂志

Objective To investigate the characteristics of attention networks impairment in Parkinson' s disease patients.Methods Attention network test was performed in 28 PD patients and 28 normal controls on the efficiency of three anatomically defined attentional networks:alerting,orienting,and executive control.Results The correct rate of attention network test was significantly lower(P0.05).The relative analysis showed that the Hoehn Yahr stage was positively correlated with the value of executive netwok(r=0.794,P