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Objective To analyze the clinical and magnetic resonance imaging(MRI)findings of solid pseudopapillary tumor(SPT)of the pancreas in male patients. Methods Clinical and MRI features of 51 patients with pathologically-proved SPT were retrospectively analyzed.The following MRI features of the lesions were analyzed:location,maximal diameter,shape,margin,capsule,solid and cystic components,signal intensity characteristics,and enhancement patterns.Results The average maximal diameter of the SPT in male patients was significantly smaller [(3.9±1.6)cm vs.(6.3±3.9)cm,P=0.035]than that of SPT in female patients.Pure solid tumors were signiciantly more common in male patients(8/14)than in female patients(9/37)(P=0.037).T-weighted images of SPT showed mainly homogenous hypo-intensity in male patients(11/14)and heterogeneous hypo-intensity in female patients(23/37)(P=0.001).Hemorrhage was more prevalent in female patients(22/37)than in male patients(2/14)(P=0.005).There were no significant differences between male and female patients regarding clinical features and other magnetic resonance features(P>0.05).Conclusions On MRI,SPT in male patients is small and shows mainly pure solid component with rare hemorrhage.The clinical and other MRI features of SPT are not different between males and females.
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<p><b>OBJECTIVE</b>To explore the related risk factors and genetic susceptibility of coronary heart disease (CHD) in old Chinese Han patients.</p><p><b>METHODS</b>In a case-control study, we enrolled 246 patients with CHD for cases, 185 cases without CHD for control. Correlation of CHD with 15 risk factors, including sex, age, smoking, drinking, hypertension, diabetes mellitus, hyperlipidemia, homocysteine (HCY), N-terminal pro-brain natriuretic peptide (NT-pro-BNP), high-sensitivity C-reactive protein (Hs-CRP), antithrombin III (ATII), cholesterol (CHOL), triglycerides (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL) were analyzed by a logistic regression analysis. Meanwhile, facilitated by USA Sequenom high-throughput single nucleotide polymorphisms (SNP) genotyping systems, 10-Plex Genes, 11 SNPs were investigated.</p><p><b>RESULTS</b>Aging, hypertension, lower ATIII were major risk factors for CHD (P < 0.05). Platelet glycoprotein GP1BA rs2243093 (-5T/C), angiotensin-converting enzyme ACE rs4332 (547C/T) and ATIII rs2227589 (893C/T) were associated with CHD in old Han Chinese patients. Mutant genotype CC of rs2243093 (-5T/C) compared with T + AT, P was 0.029 (OR = 3.41, CI: 1.19-9.75). Heterozygous TC of rs4332 (547C/T) was compared with CC + TT, P is 0.003 (OR = 0.56, CI: 0.38-0.82). T-allele carrier CT + CT of rs2227589 (893C/T) was compared with wild genotype CC, P = 0.003 (OR = 1.79, CI: 1.22-2.63).</p><p><b>CONCLUSION</b>Our study demonstrated that aging, hypertension, lower ATIII were the major risk factors of CHD. Three mechanisms associated with platelets, anti-coagulation system, the renin-angiotensin system were involved in coronary heart disease in the elderly.</p>
Subject(s)
Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Age Factors , Antithrombin III , Metabolism , Asian People , Genetics , Case-Control Studies , Coronary Disease , Ethnology , Genetics , Genetic Predisposition to Disease , Genotype , Hypertension , Polymorphism, Single Nucleotide , Risk FactorsABSTRACT
<p><b>OBJECTIVE</b>To investigate the prognostic value of ultra-sensitive pregnancy associated plasma protein-A (PAPP-A) level in the early phase of acute coronary syndrome (ACS) attack.</p><p><b>METHODS</b>Patients diagnosed as ACS were enrolled and the level of circulatory PAPP-A was measured within 12 hours after ACS attack. The patients were followed at the time of 1st, 6th, and 12th months post-ACS attack in order to observe the incidence of the cardiovascular adverse events. According to the highest quintile, the patients were divided into 2 groups: high level (≥26.08 μg/L) group and low level (<26.08 μg/L) group, to evaluate the association between the level of PAPP-A and the incidence of the cardiovascular events.</p><p><b>RESULTS</b>Compared with the low level group, the incidence of the composite outcome is significantly increased in the high level group, and the values of OR are 4.76, 4.38, 3.75 for 1st, 6th, 12th months respectively (P=0.000). For myocardial infarction (MI) + cardiac death (CD) the values of OR were 9.81, 6.08, 4.12 (P<0.01). Multivariate logistic regression analysis demonstrates that PAPP-A was an independent risk factor for the cardiovascular adverse events in the early, median, and late phase of ACS (P<0.05).</p><p><b>CONCLUSION</b>In the early phase of ACS attack, the elevation of PAPP-A is an independent risk factor for the occurrence of cardiovascular adverse events.</p>
Subject(s)
Aged , Female , Humans , Male , Middle Aged , Acute Coronary Syndrome , Blood , Diagnosis , Pregnancy-Associated Plasma Protein-A , Metabolism , Prognosis , Risk FactorsABSTRACT
Objective To explore the prevalence of intolerance to eggs and its relationship with body mass index in Beijing,China.Methods A cross sectional survey which included 12 766 adults from health sciences center of general hospital of the Chinese People's Liberation Army from August,2008 to July,2009 was carried out.Data was entered computer and organized by EpiData 3.0 software for epidemiological analysis.Nonconditional logistic regression model was used for odd ratio (OR) and 95％CIcalculation,and statistics analysis was carried out by SPSS 13.0 software.Results Positive rate of intolerance to eggs in the cohort was 28.5％.Grades of intolerance to eggs were associated with sex(P＜0.05 ).Positive rate of intolerance to eggs in females(36.5％ ) was higher than those in males (24.9％).Data from multiple regression analysis showed that intolerance to eggs was associated with sex and body mass index.Compared with males,the OR(95％CI) of female was 1.732 (1.590-1.887).Compared with normal weights,the OR (95％ CI) of low weights was 1.443 ( 1.018-2.045 ).Conclusion Sex and body mass index might be associated with intolerance to eggs.
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One case of hairy cell leukemia with survival for 10 years was reported. The patient received Interferon-alpha(2b) treatment continuously for more than 9 years and intravenous administration of fludarabine for 2 courses of treatment in the later period, and died due to complication of severer infection in thd end. The manifestation, diagnosis and treatment of hairy cell leukemia were discussed.