Progress in the effects of injury and regeneration of gustatory nerves on the taste functions in animals / 生理学报

The sensor of the taste is the taste bud. The signals originated from the taste buds are transmitted to the central nervous system through the gustatory taste nerves. The chorda tympani nerve (innervating the taste buds of the anterior tongue) and glossopharyngeal nerve (innervating the taste buds of the posterior tongue) are the two primary gustatory nerves. The injuries of gustatory nerves cause their innervating taste buds atrophy, degenerate and disappear. The related taste function is also impaired. The impaired taste function can be restored after the gustatory nerves regeneration. The rat model of cross-regeneration of gustatory nerves is an important platform for research in the plasticity of the central nervous system. The animal behavioral responses and the electrophysiological properties of the gustatory nerves have changed a lot after the cross-regeneration of the gustatory nerves. The effects of the injury, regeneration and cross-regeneration of the gustatory nerves on the taste function in the animals will be discussed in this review. The prospective studies on the animal model of cross-regeneration of gustatory nerves are also discussed in this review. The study on the injury, regeneration and cross-regeneration of the gustatory nerves not only benefits the understanding of mechanism for neural plasticity in gustatory nervous system, but also will provide theoretical basis and new ideas for seeking methods and techniques to cure dysgeusia.

Study on effect of VEGF expression level and sources on tumor induced angiogenesis by numerical simulation / 医用生物力学

Objective To investigate the effect of vascular endothelial growth factor (VEGF) expression level and sources on tumor-induced angiogenesis by numerical simulation. Methods A two-dimensional discrete mathematical model of tumor-induced angiogenesis was developed to simulate the growth of microvascular networks inside and outside of the tumor, focusing on endothelial cell proliferation, degradation, random motility, chemotaxis, haptotaxis and stromal-derived VEGF and tumor-derived VEGF. The relationship between VEGF derived by each compartment and tumor microvessel density was discussed. Results The high VEGF region was consistent with proliferating cell and tumor periphery regions in which microvascular density was also high. The simulation demonstrated that an enlargement of proliferating cell region could lead to higher VEGF expression level and higher microvascular density. However, for different types of tumors, the correlations between different VEGF expression sources and microcascular density were not significant. Conclusions The effect of VEGF expression level and source on VEGF-mediated angiogenesis can be investigated by the proposed model. Particularly, taking VEGF expression from different sources into consideration could be a useful modeling tool for anti-VEGF targeted therapies.

Effect of veneering technologies on color and translucency of Y2O3 stabilized tetragonal zirconia polycrystals all-ceramic restorations / 中华口腔医学杂志

<p><b>OBJECTIVE</b>To compare color parameters and transmittance of Y2O3 stabilized tetragonal zirconia polycrystals (Y-TZP) all-ceramic restorations using different veneering technologies.</p><p><b>METHODS</b>Fifteen disc specimens with 10 mm in diameter and (0.50 +/- 0.01) mm in thickness were fabricated of IPS e. max ZirCAD core material, and ZL1 IPS e. max ZirLiner was layered in 0.10 mm thickness. The specimens were divided into three groups randomly (n=5 per group). Group ZP was veneered 0.60 mm by heat-pressing; group ZC was veneered 0.60 mm by layering; group ZPC was veneered 0.30 mm by heat-pressing and then 0.30 mm by layering. Color parameters L*, a*, b* and transmittance of zirconia specimens were measured before and after veneering with ShadeEye NCC dental chromameter and spectrophotometer. Color saturation C* ab and color difference deltaE were calculated in the following formulae: C* ab = [(a*)2 + (b*)2](1/2), deltaE = [(deltaL*)2 + (deltaa*)2 + (deltab*)2](1/2) One-way analysis of variance and Turkey's multiple comparison test were used to analyze data (alpha = 0.05) by SPSS 10.0 statistic software. Color parameters of A2 shade tabs were measured, and color differences between each group and tab were calculated.</p><p><b>RESULTS</b>As to ZP,ZPC,ZC groups, the value of a* increased (-1.35 +/- 0.07, -0.64 +/- 0.06, -0.36 +/- 0.05) (P < 0.05), the value of b* decreased (27.01 +/- 0.07, 25.48 +/- 0.11, 23.28 +/- 0.25) (P < 0.05), and the value of C* ab decreased (27.04 +/- 0.08, 25.49 +/- 0.11, 23.28 +/- 0.25) (P < 0.05). L* and transmittance were maximum in ZP group (87.53 +/- 0.48, 1.64 +/- 0.03) and minimum in ZPC group (82.14 +/- 0.18, 1.47 +/- 0.01) (P < 0.05). Compared with standard A2 shade tab, the color difference of ZC group was minimum (delta = 1.04), and the color difference of ZP group was maximum (deltaE = 4.86).</p><p><b>CONCLUSIONS</b>Y-TZP all-ceramic restoration veneered by heat-pressing was the most transparent and lightest; while veneered by both heat-pressing and layering, the restoration was worst in translucency and the least light. The color of zirconia all-ceramic restoration veneered by layering was the most similar to standard shade tab, and the color difference was minimum.</p>

Esthetics restoration after rapid orthodontic extrusion of subgingivally fractured incisor: a case report / 华西口腔医学杂志

A case of a patient with subgingivally fractured incisor was presented. Two weeks after root canal therapy, the subgingival fragment was restored with fiber post, resin core and temporary crown. Gingivoplasty was performed around. after the subgingival fragment had been elevated in the axial direction by means of edgewise fixed appliance. Stabilized and held for 6 months, the incisor was restored with all ceramic crown. Optimal esthetic was achieved when restoration was performed after rapid orthodontic extrusion which had lifted up the fracture line above the level of the gingival line within 14 days. At 6-month follow-up, the periodontal tissues were normal and neither luxation nor relapse was noted.