ABSTRACT
Stable isotope dilution mass spectrometry(ID-MS)is a quantitative method for determining the content of unlabeled compounds with stable isotope labeled compounds as internal standard. Stable isotope dilution liquid chromatography-mass spectrometry(ID-LC-MS)has the advantages of high sensitivity, no quantitative separation of the analytes, and effective elimination of the biological matrices. The method has been widely used in quantitative analysis of biomarkers, drugs and their metabolites. In this paper, the mechanism and characteristics of ID-LC-MS are briefly introduced, and its medical applications are summarized.
ABSTRACT
<p><b>OBJECTIVE</b>To study the preparation of phenols gastric floating tablet.</p><p><b>METHOD</b>The tablets which were prepared using Eudragit IV, HPMC(K4M), MCC101 and Octadecanol as excipients were evaluated by vitro floatation and releasing performance. The pressure of preparationg was also study to select the optimal preparation.</p><p><b>RESULT</b>The tablets were successfully prepared in which the drug, Eudragit IV, Octadecanol were 31% respectively,and MCC101 was 7%. And 3-4 kg was found to be the eligible pressure.</p><p><b>CONCLUSION</b>The study was found to be effective in the process of phenols gastric floating tablet.</p>