ABSTRACT
OBJECTIVE: To synthesize the derivatives of 8-amino benzofuran[3, 2-d] pyrimidine and study their anticancer activiies. METHODS: The target compounds were synthesized through a series of reactions, and their anticancer activities in vitro were evaluated against COLO205, MCF-7 and K562 cell lines by MTT as assay. RESULTS: Nine title compounds were synthesized and confirmed by EI-MS, 1H-NMR and 13C-NMR. Compounds 2, 3d and 5c had good inhibition effect against COLO205, MCF-7 and K562 cells. The inhibition rates of compound 5c against COLO205, MCF-7 and K562 cells were 99.58%, 78.75% and 98.68% respectively at 10-4 mol · L-1. CONCLUSION: The anticancer activity of benzofuran[3, 2-d] pyrimidine derivatives is worthy of further study.
ABSTRACT
Neuro signal has many more advantages than myoelectricity in providing information for prosthesis control, and can be an ideal source for developing new prosthesis. In this work, by implanting intrafascicular electrode clinically in the amputee's upper extremity, collective signals from fascicules of three main nerves (radial nerve, ulnar nerve and medium nerve) were successfully detected with sufficient fidelity and without infection. Initial analysis of features under different actions was performed and movement recognition of detected samples was attempted. Singular value decomposition features (SVD) extracted from wavelet coefficients were used as inputs for neural network classifier to predict amputee's movement intentions. The whole training rate was up to 80.94% and the test rate was 56.87% without over-training. This result gives inspiring prospect that collective signals from fascicules of the three main nerves are feasible sources for controlling prosthesis. Ways for improving accuracy in developing prosthesis controlled by neuro signals are discussed in the end.