Research progress in study on chemical constituents and antitumor effects in Hedysarum polybotrys / 中草药

Hedysari Radix (HR) mainly consists of chemical constituents such as sacchcrides, flavonoids, phenylpropanoids, etc. HR has broad application prospects in antitumor effect. In recent years, the researches on the antitumor function of HR are frequently reported, and the main active ingredients in HR are polysaccharides, flavonoids, and saponins. The active ingredients of HR mainly inhibit the growth of tumor cells, induce the apoptosis of tumor cells, enhance the immune system, and cooperate with chemotherapy drug to exert the antitumor effect. This paper reviews the advances of the chemical constituents and antitumor effects of HR, providing theoretical basis for its further development and utilization.

The safety analysis of living-related kidney donors in short term after transplantation / 中华外科杂志

<p><b>OBJECTIVE</b>To evaluate the safety of living related donors in short term after transplantation.</p><p><b>METHODS</b>Two hundred and fifty-one cases of living related donor kidney transplantation from May 2000 to July 2007 were analysed retrospectively. There were 117 male and 134 female aged from 22 to 72 years old, with a mean of 46.6 years old. The indexes were compared including serum creatinine (SCr), creatinine clearance (CCr), glomerular filtration rate (GFR) and quality of life before and after donation. Surgical complications were followed-up.</p><p><b>RESULTS</b>Donors' SCr was (75.9 +/- 17.2) micromol/L before donation, (107.4 +/- 21.2) micromol/L on 7 d after donation, (130.4 +/- 58.2) micromol/L at the 1(st) month and (116.1 +/- 24.1) micromol/L at the 3(rd) month. There were significant difference between any 2 time points (P < 0.01). CCr was (94.4 +/- 17.5) ml/min before donation and (63.5 +/- 17.8) ml/min on 10 d after donation (P < 0.01). In 62 donors, total GFR was (82.4 +/- 21.8) ml/min before donation. On 10 d after donation, GFR of remaining kidney was (57.4 +/- 14.1) ml/min which was 34.7% higher than GFR of this kidney before donation (42.6 +/- 11.8) ml/min. There was no significant difference in quality of life before living related donors and non-donor populations (P = 0.116). Surgical complications included splenic rupture in 1 case, descending colon rupture in 1 case and wound infection in 5 cases.</p><p><b>CONCLUSION</b>Living donor kidney transplantation is safe for donors, although part of indexes would vary within normal range during the early time after donation.</p>