ABSTRACT
Objective To investigate the expression pattern of linc00346 and E2F2, and its prognostic value on liver cancer. Methods Gene expression profile data of patients with liver cancer was downloaded from the cancer genome atlas (TCGA) database. Paired t test was used to evaluate the differential expression of linc00346 and E2F2 from tissues and matched adjacent normal tissues. Co-expression analysis of linc00346 and E2F2 was performed using Pearson correlation. Log-Rank test and Cox proportional hazards regression were used to estimate prognostic value of linc00346 and E2F2. Results linc00346 and E2F2 expression were upregulated in liver cancer tissue specimens (all P＜0.05), and fold change was 2.24 and 3.72, respectively. Pearson coefficient was 0.20 (P＜0.001). Patient with linc00346 and E2F2 high expression had a 1.77 (95 % CI: 1.23-2.55) and 2.19 (95 % CI: 1.51-3.17) times higher hazard of death than those with linc00346 and E2F2 low expression, respectively. However, only E2F2 was significantly associated with the prognosis of liver cancer in multiple Cox regression. Conclusions linc00346 and E2F2 expressions are upregulated in liver cancer tissues, and patients with linc00346 and E2F2 high expressions has poor prognosis. It is of great significance to discover linc00346 and E2F2 as a novel therapeutic target for liver cancer.
ABSTRACT
<p><b>BACKGROUND</b>Human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS)-related stigma is an obstacle to the implementation of treatment, care, and support programs for people living with HIV/AIDS. This study explored the association of the HIV knowledge with the attitudes toward HIV/AIDS.</p><p><b>METHODS</b>A cross-sectional survey was conducted in HIV epidemic rural areas with 5355 participants. Their knowledge and attitudes about HIV/AIDS were assessed, and the associations of HIV transmission and non-transmission knowledge with negative attitudes towards the HIV/AIDS were analyzed.</p><p><b>RESULTS</b>Negative attitudes were significantly correlated with the HIV non-transmission knowledge and the correlation was higher than that with HIV transmission knowledge among participants who were male, 20 years old and migrant workers, students and respondents of and above junior high school. However, among those who were female, age 30 and older, illiterate with primary school education, negative attitudes were significantly associated with HIV non-transmission knowledge and the association was lower than that with HIV transmission knowledge.</p><p><b>CONCLUSIONS</b>HIV transmission knowledge and non-transmission knowledge have different influences on negative attitudes towards HIV/AIDS among different demographic subgroups.</p>