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Objective To investigate the effects of puerarin on levels of thromboxane A 2 (TXA 2) and prostaglandin I 2 (PGI 2) in plasma of rats with hyperlipidemia. Methods A total of 48 Wistar juvenile rats were randomly divided into four groups: normal diet, high fat and high cholesterol diet (HFD), HFD supplemented respectively with 1 g/kg puerarin (puerarin group Ⅰ) or 2 g/kg puerarin (puerarin group Ⅱ). After eight weeks of feeding, the rats were sacrificed for detection of the levels of lipid, TXA 2, and PGI 2. Results The blood triglycerol, total cholesterol, LDL C, TXA 2, and TXA 2/PGI 2 were significantly lower in puetarin Ⅰ and puerarin Ⅱ groups than those in HFD group, but the concentration of HDL C was significantly increased in the supplemented group( F =109 163, P =0 000; P
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Objective To investigate the effects of soy oligosaccharides and peptides on lipid levels in rat plasma.Methods Sixty healthy SD rats were randomly divided into five groups fed respectively with normal diet(ND group),high-fatty diet(HFD group),HF diet+2% soy oligosaccharides(SO group),HF diet + 3% soy peptides(SP group),HF diet+2% soy oligosaccharides+3% peptides(SOP group) for 8 weeks,and the concentrations of blood lipid and apolipoprotein were measured at 28 d and 56 d.Results As compared with HFD group,the serum levels of total cholesterol(TC),triglycerol(TG),very low density lipoprotein cholesterol(VLDL-C) and low density lipoprotein cholesterol(LDL-C) and atherosclerosis index(AI) in SO,SP and SOP groups decreased significantly,while high density lipoprotein cholesterol(HDL-C) increased significantly;the level of plasma apolipoprotein A-Ⅰ(apoA-Ⅰ) increased significantly,while apolipoprotein B(apoB) and apoB/apoA-Ⅰ ratio decreased significantly,especially in SOP group.Conclusion Soy oligosaccharides and peptides can prevent hyperlipidemia by adjusting blood lipid metabolism in vivo effectively,especially when they are combined.
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Objective To investigate the effects of hawthorn powder, refined konjac flour and their compound on the levels of lipid and NO in plasma of rats being induced to hyperlipidemia by high-fat and high-cholesterol diet. Methods Fifty adult Wistar rats were randomly divided into five groups which were fed with normal diet, high-fat and high-cholesterol diet (HFD), HFD plus hawthorn powder, HFD plus refined konjac flour, HFD plus hawthorn and konjac compound, respectively. At week 4 and 8, 20 and 30 rats respectively were sacrificed for detecting the levels of lipid and NO in the blood. Results Hawthorn powder, refined konjac flour and their compound could significantly inhibit the increase of blood total cholesterol, triglycerol, VLDL-C, LDL-C induced by HFD and can significantly increase HDL-C and NO in plasma. Conclusion Hawthorn powder, refined konjac flour and their compound have the lipid-lowering effect. The hawthorn and konjac compound has better effects on increasing HDL-D and reducing VLDL-C. So they are beneficial to the prevention of atherosclerosis.
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Objective To explore the metabolism of micronutri ents related to dark adaptation of radar operators through nutritional intervent ion. Methods A total of 34 male radar operators aged between 18 ～29 years old were randomly divided into control and experimental groups. The c ontrol group were on normal diet, and the experimental group received the supple ment of VA, Zn and Se in additional to normal diet. The experiment lasted 4 week s. The levels of serum VA, Zn and Se were measured before and after the experime nt. Results The levels of serum VA, Zn and Se in the experime ntal group were significantly higher than that in the control group after the experiment (P<0.01). Conclusion The supplement of VA, Zn an d Se for 4 weeks may elevate, the levels of serum VA, Zn and Se significantly (reached or surpassed normal levels) and suggests that VA, Zn and Se su pplementation may effectively enhance the dark adaptation of radar operators.
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Objective To explore the effects of garlic and oat and their compounds on lipid metabolism and hemorheology of hyperlipidemic rats. Methods Sixty adult Wistar rats were randomly divided into five groups (12 in each group), and fed in different cages with basic forage, hyperlipid forage, low garlicin forage, high garlicin forage, and compound forage of garlicin and oat for 8 weeks. The blood lipid and hemorheology of hyperlipidemic rats were measured. Results After the rats were fed with low garlicin forage, high garlicin forage, and compound forage for 8 weeks, the levels of TC, TG, VLDL, and LDL decreased significantly, but HDL increased significantly. The contents of the high, middle and low blood viscosity, and plasma adhesion, blood reduction viscosity and hematocrit decreased significantly in low garlicin forage group, high garlicin forage group, compound forage of garlicin and oat group. In the normal forage group, these changes were not significant. In hyperlipid forage group, the contents of serum TG and TC, plasma VLDL-C and LDL-C increased significantly, but the contents of plasma HDL-C decreased significantly. Conclusion Garlic and oat may play a role in the decrease of lipid and ameliorate hemorheology, but low-dose compound forage of garlicin and oat may facilitate lipid metabolism and prevent hyperliemia and atherosclerosis.
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Objective To explore the effect of astragalus polysaccharides (APS) and soy isoflavones (SI) on glucose metabolism in diabetic rats. Methods Healthy 60 rats were equally and randomly divided into 5 groups, normal forage group (NF), high blood sugar model group(HBS), APS high dose group intervention group (APS-H), APS low dose group (APS-L), and SI intervention group (SI). Diabetic model was inflicted by intraperitoneal injection of streptozotocin (STZ). Ordinary feed and APS high dose,low dose APS and SI interfere were respectively given for 8 weeks. Blood glucose,glycated hemoglobin,glucose and lipid levels were determined in every group. Results After APS high dose,low dose and SI were given to feed diabetic rats for 8 weeks, their blood glucose, glycated hemoglobin, glucose, TC, TG, LDL, VLDL and high blood glucose was significantly lower than the HBS group (P
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Objective To investigate the effects of micronutrients selenium(Se), vitamin E(VE), vitamin C(VC) and magnesium(Mg) on levels of TXA 2, PGI 2 in plasma of rats with hyperlipidemia induced by high fat and high cholesterol diet. Methods Sixty Wistar juvenile rats were randomly divided into five groups. Each group was fed with normal diet, high fat and high cholesterol diet (HFD), HFD+Se+VE+VC, HFD+Mg, and HFD+Se+VE+VC+Mg, respectively. After eight weeks, the rats were sacrificed for the detection of levels of lipid, TXA 2 and PGI 2 in the blood. Result Micronutrient complex (Se, VE, VC, and Mg) can significantly inhibit the increase of blood triglycerol, total cholesterol, LDL C and TXA 2 induced by HFD and can significantly increase HDL C. Conclusion Micronutrient complex (Se, VE, VC, and Mg) has the lipid lowering effect and can decrease TXA 2/PGI 2 ratio, which is beneficial to the prevention of atherosclerosis.
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This investigation shows the difference of Zu and Se status between the radar operators and non-operators. The results reveal that plasma Zn and Se contents of radar operators are significantly lower than those of the non-operators, but no statistical significance in hair.It is very likely that the plasma Zn and Se reflect recent status, because during training period the radar operators work more than 4h / day in the low illumination chamber. It suggests that the RDA of Zn and Se of radar operators should be increased in order to improve dark adaptation.
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The effect of micronutrient complex preparations on dark adaptation function was studied in human body. Sixty-four young students, 18 to 20 years of age, were divided into four groups. Under the normal dietary condition, the experimental groups were supplemented with different microcutrient complex preparations for two weeks.Before and after the experiment serum vita- min A and zinc level, quick dark adaptation time, near-sighted in dim light time and absolute threshold were determined. It was found that dark adaptation was much improved in the group supplemented with adequate vitamin A as well as other vitamins and zinc. So we suggested that micronutrient complex preparation should be given to operators who will concentrate their sight in low illuminance for maintaining their visual function.
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This paper reports a study regarding the verity of the hypocholestero-lemic effect of konjac-polysaccharide. The konnyaku powder (KP) used in this study was prepared and refined from the tubers of Amorphophallus ko-njac K. Koch and contained 84.8% of glucomannan. Male and female Spra-ue-Dawley rats aged 5 weeks were divided into 5 groups and fed on normal basal diet, hypercholesterolemic diet (control diet) and 3 test diets (i.e. KP was added to the control diet at a dosage of 2.5%, 5% or 10%) respe- ctively, for 12 weeks.The results obtained from this study showed that KP could markedly lower the level of the cholesterol in sera and livers of rats feeding hyper-cholesterolemic diets. At the end of the 4th week of the feeding experiment, the serum cholesterol level of the 5% and the 10% KP groups, and the liver cholesterol level of the 10% KP group were shown to be significantly lower than those of the control group. At the end of the 12th week, serum cholesterol levels of all the 3 KP groups were found to be lowered to the level of the normal group and so did the liver cholesterol level of the 10% KP group. The lipotropic (anticholesteatosis) effect of KP was also confirmed by the hepatic histopathological examination. Besides the hypocholest-eroletmic eftect, KP diets can also increase the bulk of stool. Finally, there were not any harmful effects on the absorption and utilization of Ca, Fe, Zn and Cu being found.