ABSTRACT
Objective:To explore the related factors and treatment effect observation of Parkinson disease(PD) accompanied by depression.Methods:Two hundred patients with PD admitted to Baoding Zhuozhou Baoshihua Hospital from March 2016 to March 2020 were selected. According the scores of Hamilton depression inventory 24-item version (HAMD-24), they were divided into the case group (PD accompanied by depression, HAMD-24≥8 scores, 98 cases) and the control group (PD without depression, HAMD-24<8 scores,102 cases). Single factor analysis and multivariate regression analysis were used to analyze the influencing factors of PD accompanied by depression. The patients in the case group were divided into psychological treatment group and non-psychological treatment group by random number table method, each group with 49 cases. The differences in depression degree, quality of life and sleep quality before and after treatment between the two groups were compared.Results:The incidence rate of PD accompanied by depression was 49.0% (98/200). The multivariate regression analysis showed that the Hoehn-Yahr classification (H-Y classification), Pittsburgh Sleep Quality Index (PSQI) scores and abnormal marital status were the influence factors of PD accompanied by depression ( P<0.05); the education years was the protective factor of PD accompanied by depression ( P<0.05). After treatment, the scores of HAMD-24 and PSQI in the psychological treatment group and the non-psychological treatment group were decreased, and the scores of HAMD-24 and PSQI in the psychological treatment group were lower than those in the non-psychological treatment group: (11.78 ± 2.94) scores vs. (15.55 ± 3.91) scores, (5.18 ± 1.05) scores vs. (5.74 ± 1.12) scores, the differences were statistically significant ( P<0.05). After treatment, the improved degree of scores of five item of HAMD-24 in the psychological treatment group were higher than those in the non-psychological treatment group, the differences were statistically significant ( P<0.05). Conclusions:PD accompanied by depression is affected by multiple factors. Strengthening psychological treatment can reduce the degree of depression in patients with PD accompanied by depression and improve the quality of sleep and life.