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Objective To observe the clinical efficacy and safety of transhepatic arterial chemoemboli-zation (TACE)combined with radiofrequency ablation (RFA)in the treatment of colorectal cancer with liver metastasis. Methods The data of 92 patients with colorectal cancer with liver metastasis admitted to Nanyang First People's Hospital of Henan Province from January 2014 to January 2016 were retrospectively analyzed. A total of 46 patients treated with TACE were selected as the TACE group,and another 46 patients treated with TACE and RFA were selected as the combined group. The clinical efficacies of the two groups were compared, and the changes of Karnofsky functional status (KPS)scores before and after treatment in the two groups were analyzed. The incidences of complications in the two groups were calculated. Patients in the two groups were followed up,and the progress-free survival (PFS)and overall survival (OS)were calculated. Results The disease control rate of the combined group was 82. 61％ (38 / 46),and that of the TACE group was 63. 04％(29 / 46). The disease control rate of the combined group was higher than that of the TACE group (χ2 = 4. 449, P = 0. 035). Before treatment,the KPS scores of the combined group and the TACE group were 71. 84 ± 4. 37, 72. 22 ± 4. 26,with no statistically significant difference (t = 0. 423,P = 0. 673). After treatment,the KPS scores of the two groups were higher than those before treatment,and the KPS score of the combined group was higher than that of the TACE group (79. 81 ± 6. 15 vs. 75. 86 ± 6. 02;t = 3. 108,P = 0. 003). The incidence of complications was 54. 35％ (25 / 46)in the combined group and 41. 30％ (19 / 46)in the TACE group. The difference between the two groups was not statistically significant (χ2 = 1. 568,P = 0. 210). The median PFS and OS in the TACE group were 12. 6 and 20. 7 months,and those in the combined group were 18. 9 and 28. 2 months. The PFS and OS of the combined group were longer than those of the TACE group (χ2 = 72. 025, P < 0. 001;χ2 = 26. 580,P < 0. 001). Conclusion TACE combined with RFA is effective in the treatment of liver metastasis of colorectal cancer,which can effectively improve the KPS score of patients,prolong the PFS and OS,and do not increase the risk of complications.
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Objective To explore the predictive value of CT image texture analysis for early enlargement of hypertensive intracerebral hemorrhage.Methods One hundred and eight patients with hypertensive intracerebral hemorrhage were divided into enlarged hematoma group (positive group)and non-enlarged hematoma group (negative group),according to whether the volume of hematoma on 24 h follow up CT scan was more than 30% or 6 mL of the baseline CT.Phillis Radiomics Tool V93 software was used to segment the hematoma on CT plain scan images of two groups,four features of first-order and three of gray-level co-occurrence matrix (GLCM),thirteen of gray-level size zone matricx (GLSZM)and eleven of gray-level run-length matricx (GLRLM)were obtained.The differences of thirty-one texture features between the two groups were compared.The ROC curves of the features with statistical differences were analyzed.The independent predictors of early enlargement of intracerebral hemorrhage were screened by Logistic multivariate regression model.Results Among the one hundred and eight patients,twenty-eight were positive group and eighty were negative group.Skewness and long run low gray-level emphasis (LRLGE)in positive group were significantly higher than those in negative group (P＜0.05).There was no significant difference in the remaining twenty-nine features between the two groups (P＞0.05).ROC curve analysis showed that the AUC of Skewness,LRLGE and their combined diagnosis were 0.634,0.814 and 0.828,respectively.The independent variables were screened by stepwise regression analysis.The LRLGE (OR＝1.238,95%CI＝1.009－1.51 9,P＜0.05)was selected as the regression model, suggesting that LRLGE was an independent predictor of the early enlargement of intracerebral hemorrhage.Conclusion Texture analysis of CT images is helpful to predict the early enlargement of hypertensive intracerebral hemorrhage,and LRLGE based on GLRLM algorithm can be used as an independent predictor.
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Objective@#To observe the clinical efficacy and safety of transhepatic arterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) in the treatment of colorectal cancer with liver metastasis.@*Methods@#The data of 92 patients with colorectal cancer with liver metastasis admitted to Nanyang First People′s Hospital of Henan Province from January 2014 to January 2016 were retrospectively analyzed. A total of 46 patients treated with TACE were selected as the TACE group, and another 46 patients treated with TACE and RFA were selected as the combined group. The clinical efficacies of the two groups were compared, and the changes of Karnofsky functional status (KPS) scores before and after treatment in the two groups were analyzed. The incidences of complications in the two groups were calculated. Patients in the two groups were followed up, and the progress-free survival (PFS) and overall survival (OS) were calculated.@*Results@#The disease control rate of the combined group was 82.61% (38/46), and that of the TACE group was 63.04% (29/46). The disease control rate of the combined group was higher than that of the TACE group (χ2=4.449, P=0.035). Before treatment, the KPS scores of the combined group and the TACE group were 71.84±4.37, 72.22±4.26, with no statistically significant difference (t=0.423, P=0.673). After treatment, the KPS scores of the two groups were higher than those before treatment, and the KPS score of the combined group was higher than that of the TACE group (79.81±6.15 vs. 75.86±6.02; t=3.108, P=0.003). The incidence of complications was 54.35% (25/46) in the combined group and 41.30% (19/46) in the TACE group. The difference between the two groups was not statistically significant (χ2=1.568, P=0.210). The median PFS and OS in the TACE group were 12.6 and 20.7 months, and those in the combined group were 18.9 and 28.2 months. The PFS and OS of the combined group were longer than those of the TACE group (χ2=72.025, P<0.001; χ2=26.580, P<0.001).@*Conclusion@#TACE combined with RFA is effective in the treatment of liver metastasis of colorectal cancer, which can effectively improve the KPS score of patients, prolong the PFS and OS, and do not increase the risk of complications.
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Objective To analyze the specific IgE test results and the distribution of allergens in patients with allergic diseases in Shenzhen area .Methods Western blot was used to detect inhaled and food specific IgE in 2154 patients with allergic diseases ,and the types and distribution of allergens were analyzed .Results The total positive rate of allergen specific IgE was 48 .88％ .More than 20％ of the patients were allergic to more than two allergens .The most common allergies were dust mites ,freshwater fish and sea fish .The posi-tive rate of IgE in male allergens was higher than that in females ,and the difference was statistically signifi-cant (P<0 .05) .The positive rate of allergen specific IgE in different age groups was statistically significant (P<0 .001) .The positive rate of dust mites increased year by year before the age of 18 ,and then decreased year after year .The positive rate of chicken protein and milk showed a significant downward trend after 7 years old .The positive rate of allergen IgE in patients with different diseases was statistically significant (P<0 .001) .The positive rate of dust mite combination in rhinitis patients was the highest ,49 .94％ .Conclu-sion The main allergen of allergic diseases in Shenzhen area is dust mites combination ,freshwater fish com-bination and sea fish combination .The main food allergen of children is egg and milk .The main allergen of a-dult is dust mites combination and fish ,and the patients with rhinitis are high sensitized people of dust mites combination .
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Objective To investigate the relationship between pulmonary function,serum inflammatory factors and coronary artery disease in elderly patients with hypertension.Metbods One hundred and fifty-two patients with hypertensive disease were involved.According to whether the patients had coronary artery disease,the patients were divided into hypertension with coronary artery disease group included 84 patients and non-combined coronary artery disease group included 68 patients.Results Age (75.23-± 7.49years vs 71.42 ± 8.21years),triglyceride (1.59 ± 0.41mmol/L vs 1.41 ± 0.63mmol/L) serum creatinine (82.42 ± 39.27μmol/L vs 70.39 ±25.76μmol/L),blood urea nitrogen (7.85 ± 4.31mmol/L vs 6.12 ± 2.49mmol/L),IL-2 (567.32 ± 191.53pg/d1 vs 501.26 ±214.74pg/dl),IL-6 (3.95 ± 2.92pg/dl vs 3.04 ± 2.61pg/dl) and CRP (1.75 ± 1.84mg/dl vs 1.04 ± 2.01 mg/dl) of hypertension with coronary artery disease group were higher than hypertension non-combined coronary artery disease group,however FEV1％ (83.42％ ± 24.57％ vs 92.15％ ± 19.38％) and FEV1/FVC (62.91 ± 13.65 vs 70.24 ± 9.42) were more lower.There was significant difference (P ＜ 0.05).From the multiple linear regression analysis of relevant factors,we found that FEV1 ％ (P =0.005),FEV1/FVC (P =0.003),IL-2 (P =0.012) and CRP (P =0.009) was independently associated with hypertension complicated with coronary artery disease.From the analysis between IL-2,CRP and FEV1％,FEV1/FVC of hypertensive patients with coronary artery disease,we found that IL-2 was significantly negatively correlated with FEV1 ％ (r =-0.391,P =0.000) and FEV1/FVC (r =-0.571,P =0.000),and CRP was also was significantly negatively correlated with FEV1％ (r =-0.437,P =0.000) and FEV1/FVC (r =-0.559,P =0.000).Conclusion We find that pulmonary function and serum inflammatory factors are the risk factors of the coronary artery disease in elderly patients with hypertension.
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Objective To investigate the relationship between pulmonary function,serum inflammatory factors and coronary artery disease in elderly patients with hypertension.Metbods One hundred and fifty-two patients with hypertensive disease were involved.According to whether the patients had coronary artery disease,the patients were divided into hypertension with coronary artery disease group included 84 patients and non-combined coronary artery disease group included 68 patients.Results Age (75.23-± 7.49years vs 71.42 ± 8.21years),triglyceride (1.59 ± 0.41mmol/L vs 1.41 ± 0.63mmol/L) serum creatinine (82.42 ± 39.27μmol/L vs 70.39 ±25.76μmol/L),blood urea nitrogen (7.85 ± 4.31mmol/L vs 6.12 ± 2.49mmol/L),IL-2 (567.32 ± 191.53pg/d1 vs 501.26 ±214.74pg/dl),IL-6 (3.95 ± 2.92pg/dl vs 3.04 ± 2.61pg/dl) and CRP (1.75 ± 1.84mg/dl vs 1.04 ± 2.01 mg/dl) of hypertension with coronary artery disease group were higher than hypertension non-combined coronary artery disease group,however FEV1％ (83.42％ ± 24.57％ vs 92.15％ ± 19.38％) and FEV1/FVC (62.91 ± 13.65 vs 70.24 ± 9.42) were more lower.There was significant difference (P ＜ 0.05).From the multiple linear regression analysis of relevant factors,we found that FEV1 ％ (P =0.005),FEV1/FVC (P =0.003),IL-2 (P =0.012) and CRP (P =0.009) was independently associated with hypertension complicated with coronary artery disease.From the analysis between IL-2,CRP and FEV1％,FEV1/FVC of hypertensive patients with coronary artery disease,we found that IL-2 was significantly negatively correlated with FEV1 ％ (r =-0.391,P =0.000) and FEV1/FVC (r =-0.571,P =0.000),and CRP was also was significantly negatively correlated with FEV1％ (r =-0.437,P =0.000) and FEV1/FVC (r =-0.559,P =0.000).Conclusion We find that pulmonary function and serum inflammatory factors are the risk factors of the coronary artery disease in elderly patients with hypertension.
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Objective To investigate the value of brain natriuretic peptide and heart failure ultrasound in the diagnosis of early chronic heart failure.Methods One hundred and forty-six patients with chronic heart failure and seventy-five healthy people with normal heart function were involved.According to NYHA classification,patients with chronic heart failure were divided into grade Ⅰ,Ⅱ,Ⅲ and Ⅳ,including grade Ⅰ twenty six,grade Ⅱ forty three,grade Ⅲ forty eight and grade Ⅳ twenty nine patients.Results There was no significant difference in the general information between patients with chronic heart failure and healthy people with normal heart function (P ＞ 0.05),including age,sex,ALT,AST,fasting blood glucose,total cholesterol,triglyceride,serum creatinine and CRP.The BNP of the two groups were compared,and we found the BNP of grade Ⅱ (181.19 ±48.06),Ⅲ (279.26 ±49.45) and Ⅳ (882.34 ± 388.71) patients was significantly higher than healthy people (54.12 ± 25.87),and with the severity of heart failure,BNP increased gradually.There was statistically significant the difference (P ＜ 0.05).but there was no significant difference between the patients of grade Ⅰ (77.14 ± 24.32) and healthy people (P ＞ 0.05).Compared with healthy people(0.78 ± 0.42),HFEI was significantly higher in patients with chronic heart failure.The HFEI of grade Ⅰ (1.58 ± 0.89),Ⅱ (2.64 ± 1.07),Ⅲ (4.47 ± 1.39) and Ⅳ (6.33 ± 1.61) were compared,we found HFEI increased gradually with the severity of heart failure,and the difference was statistically significant (P ＜ 0.05).From the analysis between BNP and HFEI,we found that BNP was significantly positively correlated with HFEI in patients with chronic heart failure (r =0.935,P =0.000).From ROC curve analysis,the area under the ROC curve of early chronic heart failure was 0.970,showing that plasma BNP combined with HFEI could be accurately diagnosed early chronic heart failure.Conclusion We find plasma brain natriuretic peptide and heart failure echocardiography index can be used in early diagnosis of chronic heart failure.