ABSTRACT
Myelodysplastic syndromes (MDS) is a group of malignant clonal hematopoietic stem cell disorders. With the application of molecular biology techniques in a wide range of scientific research and clinical practice, studies have shown that gene mutation is one of the key factors in the occurrence and progression of MDS. Great clinical heterogeneity of MDS is associated with diversity of genes mutation, and genes research will play an increasingly important role in the diagnosis, classification and prognosis of MDS. In this review, the recent advances on these common genes will be summarized.
ABSTRACT
Objective The aim of this research was to study the biological and clinical features of cervical cancer and precursor lesions Methods Nuclear DNA was analyzed by image cytometry (ICM) in 125 embedded tissue 5 ?m sections stained with Feulgen stain Samples included normal cervical squamous epithelium ( n =11), cervical intraepithelial neoplasiaⅠ (CINⅠ) ( n =22), CINⅡ ( n =17) and CINⅢ ( n =13), cervical neoplasm ( n =62) Results The mean DNA content, nuclear area increased progressively from normal cervical epithelium, CINⅠ , CINⅡ , CINⅢ to invasive squamous carcinoma Statistical analysis revealed significant difference ( P