ABSTRACT
<p><b>OBJECTIVE</b>To study the solubilization effect of 2-hydroxypropyl-beta-cyclodextrin(HPCD) on paeonolum at various pH value.</p><p><b>METHOD</b>Phase-solubility method was adopted to study the solubilization effect at 25 degrees C and UV spectrohotometer was used to determine paeonolum content.</p><p><b>RESULTS</b>The apparent solubility of paeonolum was significantly enhanced by increased HPCD concentration. The apparent stability constant of paeonolum compounds was calculated up to 1 425 in which pH was 3 and HPCD concentration was 133.33 mmol x L(-1). The solubility of paeonolum came up to 10 mg x mL(-1).</p><p><b>CONCLUSION</b>HPCD is an ideal solubilizer for paeonolum.</p>
Subject(s)
2-Hydroxypropyl-beta-cyclodextrin , Acetophenones , Chemistry , Drug Stability , Excipients , Hydrogen-Ion Concentration , Paeonia , Chemistry , Plants, Medicinal , Chemistry , Solubility , beta-CyclodextrinsABSTRACT
<p><b>OBJECTIVE</b>To study the chemical constituents of Fagopyrum cymosum.</p><p><b>METHOD</b>The chemical constituents were isolated by various chromatographic methods and their structures were elucidated by the analysis of spectral data and physiochemical properties.</p><p><b>RESULT</b>Four phenolic acid derivatives were isolated from F. cymosum. The chemical structures were elucidated as trans-p-hydroxy cinnamic methyl ester (I), 3, 4-dihydroxy benzamide (II), protocatechuic acid (III), protocatechuic acid methyl ester (IV).</p><p><b>CONCLUSION</b>Compounds I, II, IV were obtained from the genus Fagopyrum for the first time.</p>