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Chinese Medical Journal ; (24): 1851-1856, 2005.
Article in English | WPRIM | ID: wpr-282873

ABSTRACT

<p><b>BACKGROUND</b>Live attenuated hepatitis A vaccine (H2 strain) is widely applied in prevention of hepatitis A epidemic in China and other countries now. It is essential to observe and confirm the vaccine immune efficacy, population antibody level and its persistent efficacy after mass immunization.</p><p><b>METHODS</b>A total of 220 children with negative anti-HAV antibody (aged 1 - 3 years) were taken for follow-up assay to observe seroconversion and geometric mean titre (GMT) level 2 months, 12 months, 6 years, and 10 years after inoculation. Another survey sampled from subjects of different age groups (3, 6, 9, 15, 18, 25 and 35 years) to compare anti-HA antibody positive rate before and after inoculation performed 10 years previously. Epidemiological observations were taken for 10 years to evaluate the relationship between vaccine coverage and hepatitis A morbidity. Serum antibody to HAV was detected by enzyme linked immunoassay (ELISA, calibrated by WHO international reference) and ABBOTT Axsym HAVAB microparticle enzyme immunoassay.</p><p><b>RESULTS</b>Seroconversion in follow-up assay 2 months and 10 years after inoculation was 98.6% and 80.2% respectively. For children, the vaccination anti-HA antibody positive rates were significantly different before and after 10 years, 7.69% cf 70.45% (aged 3 years) and 52.58% cf 71.78% (aged 18 years). When vaccine coverage rose from 57% to 74%, there were no any HA epidemics. When vaccine coverage reached 85%, there were no any HA cases. With vaccine coverage between 85% and 91%, there were no any HA cases in cohorts from the age of 1 year to 15 years during the 10 years.</p><p><b>CONCLUSIONS</b>Live attenuated hepatitis A vaccine has an obvious long-term effectiveness in prevention and control of HA epidemics through mass vaccination.</p>


Subject(s)
Adolescent , Adult , Child , Child, Preschool , Humans , Enzyme-Linked Immunosorbent Assay , Follow-Up Studies , Hepatitis A , Hepatitis A Vaccines , Allergy and Immunology , Hepatitis Antibodies , Blood , Immunoglobulin G , Blood , Mass Vaccination , Vaccines, Attenuated , Allergy and Immunology
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