ABSTRACT
Objective To analyze the relationship between acute exacerbation of chronic obstructive disease (COPD) hospitalization and climate change in Enshi, Hubei province, and to provide theoretical basis for the prevention and treatment of COPD in Enshi . Methods Patients with acute COPD in Enshi district of Hubei Province from January 2019 to December 2019 were selected, and the clinical data of all patients on admission, including symptoms, signs, onset month, lung function indicators and serum inflammatory factors, were analyzed . FEV1% predictive value, FEV1/FVC and other lung function indexes were determined by pulmonary function detector. CRP and WBC levels were determined by biochemical detector. At the same time, meteorological factors data in Enshi , were collected , including monthly mean temperature, monthly mean humidity, monthly mean wind speed , monthly mean sunshine in Hubei province , etc. Spearman linear correlation was used to analyze the meteorological factors affecting the number of hospitalized AECOPD patients . Results The age of patients with ACUTE exacerbation of COPD was mainly 70-79 years old (34.63%) in Enshi area of Hubei Province , followed by 60-69 years old (22.49%) , and the lowest was 40-49 years old (13.75%). The incidence time mainly concentrated to may for the peak in March , November to January for the secondary peak , June to October for a relatively small number of cases. The main symptoms of COPD acute recombination are frequent cough , shortness of breath , increased sputum volume, etc., while the main signs are emphysema , wheezing , dry and wet rales . The predictive value of FEV1 and FEV1/FVC value of acute recombinant COPD were significantly lower than those of non-acute recombinant COPD (P1=-0.519 , r2=-0.428, P1=0.124 , r2=0.176, P>0.055) . Conclusion The number of patients with ACUTE exacerbation of COPD shows obvious seasonality, and the occurrence of AECOPD should be actively prevented in months with great changes in temperature and humidity.