ABSTRACT
<p><b>OBJECTIVE</b>To make a study of the influence of the intervene of traditional Chinese medicine on cytokine level in benign prostatic hyperplasia.</p><p><b>METHOD</b>The patients were divided into treatment group (group A), control group (group B) and healthy group (group C) with the randomly compared researching method. Group A were given Qianliening Tang (QLNT), daily potion, two times a day. Group B were given Qianliekang, three times a day, three pills each time. The course of both treatment lasted for 8 weeks.</p><p><b>RESULT</b>Before treatment, TNF-alpha, IL-17/IL-10, IL-4 in group A and B are obviously out of order compared with group C (P < 0.01). After the treatment, TNF-alpha, IL-17 in group A decreased dramatically and IL-10, IL-4 increased, which shows great differences compared with those before treatment and with group B (P < 0.01), but still can't reach to group C level.</p><p><b>CONCLUSION</b>Qian liening Tang can efficiently regulate the level of suppressive inflammatory cytokines and proinflammatory cytokines. It provides scientific experimental basis for clinical diagnosis and treatment of the disease.</p>
Subject(s)
Aged , Aged, 80 and over , Humans , Male , Middle Aged , Adjuvants, Immunologic , Cytokines , Blood , Drugs, Chinese Herbal , Pharmacology , Interferon-gamma , Blood , Interleukin-10 , Blood , Interleukin-17 , Blood , Interleukin-4 , Blood , Leukocytes, Mononuclear , Medicine, Chinese Traditional , Methods , Phytotherapy , Prostatic Hyperplasia , Blood , Drug Therapy , RNA, Messenger , Synovial Membrane , Tumor Necrosis Factor-alpha , BloodABSTRACT
Objective To evaluate the prognostic factors affecting postoperative recurrence and progression in patients with superficial bladder transitional cell carcinoma(SBTCC). Methods From 2000 to 2004,150 patients with SBTCC were treated, of which 120 patients were followed up. The possible prognostic factors including clinical and pathological figures were analyzed by Cox's proportional hazard model in these patients. Results The mean fol-low-up period was 84.7 months. The recurrence rates at 3-year,5-year were 27.5% and 36.7% respectively. The main variables affecting recurrence were histological grades,tumor stage,tumor number and recurring tumor,and the first three were the independent risk factors. The progression rotes at 3-year,5-year were 9. 2% and 17.5%. The main variables affecting progression were histological grade,tumor stage, tumor number and recurring tumor, and the first one was the independent risk factor. Conclusion The main variables affecting progression were histological grade, tumor stage,tumor number and recurring tumor,and the first one were the independent risk factor.