ABSTRACT
Objective:To explore the efficacy and safety of azithromycin combined with mosapride in the patients with diabetic gastroparesis ( DGP) . Methods:Totally 70 cases of patients with DGP were randomly divided into the observation group and the control group. All the patients were given drugs to control the blood sugar ( injection of insulin or oral administration of hypoglycemic drugs) . The patients in the observation group were given azithromycin enteric-coated tablets 0. 25g per time, once a day, and mosapride tablets 5mg per time, three times a day, while the patients in the control group were only given mosapride tablets 5mg per time, three times a day. The treatment course was 4 weeks. The clinical curative effect and drug adverse reactions ( ADR) in the two groups after the med-ical treatment were observed, and the reoccurrence rate after one-year following-up was compared as well. Results: After the 4-week treatment, the total clinical efficiency in the observation group was much higher than that in the control group (94. 29% vs. 77. 14%, P0. 05). The reoccurrence rate in the observa-tion group was much lower than that in the control group (P<0. 05). Conclusion:Azithromycin combined with mosapride shows reli-able curative effect in the patients with DGP with high security, which can effectively reduce the reoccurrence rate of the patients.