ABSTRACT
<p><b>OBJECTIVE</b>To study the protective effects of Isodon lophanthoides var. gerardianus (ILVG) aqueous extract on the acute hepatic injury induced by carbon tetrachloride (CCl4) in rats.</p><p><b>METHOD</b>Sixty rats were allocated into control group, model group, low, middle and high dosage group and Bifendate group randomly. At the test group, rats received either ILVG aqueous extract (15, 7.5, 3.75 g x kg(-1)) or Bifendate (45 mg x kg(-1)) by gastric perfusion daily for 10 consecutive days. In 1st, 4th, 7th and 10th days, 10% CCl4 (2 mL x kg(-1)) was given to rats by intraperitoneal (ip) injection. The rats were killed 24 h after the last adminiction with drug, the levels of ALT, AST, ALP and total bilirubin in serum were analyzed, the body weight, liver weight, spleen weight and thymus weight of each rat were measured, and the hepatic tissue pathology was observed.</p><p><b>RESULT</b>ILVG could decrease the ALT, AST, ALP and T-Bil in serum, restrain the enlargement of liver and the shrinkage of thymus, and reduce the necrosis in pathological observation.</p><p><b>CONCLUSION</b>ILVG aqueous extract possesses the effects of protecting on the acute hepatic injury induced by CCl4 in rats.</p>
Subject(s)
Animals , Female , Male , Rats , Alanine Transaminase , Blood , Alkaline Phosphatase , Blood , Aspartate Aminotransferases , Blood , Bilirubin , Blood , Carbon Tetrachloride Poisoning , Chemical and Drug Induced Liver Injury , Blood , Pathology , Drugs, Chinese Herbal , Pharmacology , Isodon , Chemistry , Liver , Pathology , Plants, Medicinal , Chemistry , Protective Agents , Pharmacology , Random Allocation , Rats, Sprague-DawleyABSTRACT
AIM: To study the protective effects of Xiaoyan Lidan Tablet(Herba Andrographis,Herba Rabdosiae serrae,Radix Sophorae Flavescentis,etc) on acute hepatic injury in rats. METHODS: Acute hepatic injury was induced by intraperitoneal(ip) injection of carbon tetrachloride and D-galactosamine,respectively.The levels of ALT,AST,ALP,TBA,total bilirubin(T-Bil),total protein (TP) and albumin(ALB) in serum were analyzed.The body weight,liver weight,spleen weight and thymus weight of each rat were measured.The hepatic glycogen content was analyzed individually.Liver tissue pathology was observed. RESULTS: Xiayan Lidan Tablet can decrease ALT,AST,ALP,TBA and T-Bil in serum,reduce necrosis in pathological observation. CONCLUSION: Xiaoyan Lidan Tablet gives the protective effects to acute hepatic injury induced by CCl_4 and D-Gal in rats.