The relationship between overweight and obesity, high blood pressure and left ventricular hypertrophy in adolescents in Tangshan / 中国医师杂志

Objective:To explore the relationship between overweight and obesity, high blood pressure and left ventricular hypertrophy (LVH) in adolescents in Tangshan.Methods:Through cluster sampling, 1 023 adolescents aged 7-18 were selected from primary and secondary schools in Tangshan (January 2018 to January 2020). Questionnaire survey, blood pressure, weight, height measurement and ultrasound examination were performed. The incidence of LVH in 1 023 adolescents was statistically analyzed. 1 023 adolescents were divided into four groups according to whether they were overweight or obesity (overweight: weight for age Z score >2; obesity: height for age Z score >2) and whether blood pressure was high [high blood pressure: systolic blood pressure (SBP) or diastolic blood pressure (DBP)≥gender/age P 90 and <P 95; hypertension: SBP/DBP≥gender/age P 95]. The left ventricular mass index (LVMI) and the incidence of LVH were compared among different body weight and blood pressure. The relationship between overweight and obesity, high blood pressure and LVH was analyzed by multivariate logistic regression. Results:Among 1 023 adolescents, 98 were LVH and 925 were normal; the BMI, SBP, DBP, high blood pressure rate, and overweight and obesity rate in LVH group were significantly higher than normal group ( t=13.179, 3.239, 4.093; χ 2=12.998, 120.861, P<0.05). The LVMI level of each group increased with the increase of body weight and blood pressure ( P<0.05); the incidence of LVH in the overweight and obesity group with high blood pressure was significantly higher than that in the overweight and obesity group with normal blood pressure; the incidence of LVH was significantly higher in the overweight and obesity group with normal blood pressure was significantly higher than that in the high blood pressure and normal weight group ( P<0.05). Multivariate logistic regression analysis showed that compared with the normal blood pressure and weight groups, the risk of LVH increased significantly in the obesity and overweight group with high blood pressure and normal blood pressure [ OR (95% CI): 12.04(4.95-29.14), 14.32(5.66-36.26)], while the risk of LVH did not increase significantly in the high blood pressure and normal weight group [ OR (95% CI): 2.53(0.61-10.21)]. Conclusions:The adolescents in Tangshan area have a higher incidence of LVH. Simple high blood pressure will not increase the risk of LVH. However, overweight and obesity combined with high blood pressure can further increase the risk of LVH. We should actively prevent high blood pressure, control overweight and obesity, and reduce the risk of abnormal cardiac structure in adolescents.

Study on Protective Effect of Total Flavonoids from the Leaves of Mongolian Medicine Choerospondias axillaris on Myocar- dial Ischemia Reperfusion Injury Model Rats / 中国药房

OBJECTIVE： To investigate the protective effect of total flavonoids from the leaves of Choerospondias axillaris （TFLC） on myocardial ischemia reperfusion injury （MIRI） model rats. METHODS： Male SD rats were randomly divided into sham operation group， model group， positive control group （verapamil， 0.02 g/kg）， TFLC low-dose and high-dose groups （0.1， 0.4 g/kg）， with 10 rats in each group. Administration groups were intragastrically given relevant medicine （2 mL/100 g）； sham operation group and model group were given constant volume of normal saline intragastrically， once a day， for consecutive 7 d. After last medication， MIRI model was induced by modified ligation method. The times and duration of ventricular tachycardia （VT） and ventricular fibrillation （VF） in rats were recorded with biological function experiment system during reperfusion period.The activity of CK and contents of TNF-α， IL-6， NF-κB and NO in serum were determined by ELISA double antibody clip art assay. The morphological characteristics of myocardial tissue was observed by HE staining. The myocardial infarction scope （i.e. the ratio of myocardial tissue mass to ventricular mass） was measured by TTC method. RESULTS： Compared with sham operation group， the times and duration of VT and VF were increased or prolonged significantly in model group； CK activity， serum contents of TNF-α， IL-6 and NF-κB were enhanced or increased significantly， while NO content was decreased significantly （P＜0.05 or P＜0.01）. Obvious myocardial infarction focus， serious cell structure damage， disorderly muscle fibers arrangement， cell nucleus pyknosis and accompanied inflammatory cell infiltration were all observed in cardiac tissue； the mass of infarcted myocardial tissue and ventricular as well as the scope of myocardial infarction increased significantly （P＜0.01）. Compared with model group， the times and duration of VT and VF were decreased or shortened significantly in administration groups； CK activity， serum contents of TNF-α， IL-6， NF-κB were decreased significantly， while NO content was increased significantly （P＜0.05 or P＜0.01）. The above symptoms of myocardial injury were improved；the mass of infarcted myocardial tissue and ventricular as well as the scope of myocardial infarction was significantly reduced （P＜0.05 or P＜0.01）. CONCLUSIONS： TFLC can relieve MIRI-induced ischemic arrhythmia and myocardial damage， reduce the release of inflammatory factors， promote the recovery of myocardial and endothelial cell function， reduce the scope of myocardial infarction and has a certain protective effect.

Needle-stick injuries among health care workers and protective strategies in a hospital / 中国感染控制杂志

Objective To investigate the condition and causes of needle-stick injuries among health care workers(HCWs), and explore effective strategies for preventing needle-stick injuries.Methods Needle-stick injuries recorded by healthcare-associated infection management department in a hospital between January 2013 and December 2015 were surveyed retrospectively.Results 164 HCWs suffered needle-stick injuries, including 71 (43.29%) doctors, 81 (49.39%) nurses, and 12 (7.32%) other HCWs.The number of injuries in 2013, 2014, and 2015 were 47(28.66%), 54(32.93%),and 63(38.41%)respectively.152(92.68%), 9(5.49%),and 3(1.83%)injuries were caused by contaminated medical instruments, uncertain-contaminated medical instruments, and non-contaminated medical instruments.Among 164 cases of needle-stick injuries, 67(40.85%) occurred in operating rooms, 141 (85.98%) were finger injuries;the main causes of needle stick injuries were carelessness, busy work and nonstandard manipulation(n=115, 70.12%), most doctors suffered needle stick injuries due to the lack of experience (52.11%), most nurses suffered needle stick injuries due to carelessness, busy work and nonstandard manipulation(93.83%).Conclusion Needle stick injuries among HCWs increased year by year, strategies should be implemented to reduce the occurrence of needle injuries, including strengthening occupational protection consciousness among HCWs, strengthening construction of healthcare-associated infection management system, and improving medical environment.

Efficacy and psychological intervention of budesonide combined with terbutaline inhalation in the treatment of children with asthma / 中国生化药物杂志

Objective To study the efficacy and psychological intervention of budesonide combined with terbutaline inhalation in the treatment of children with asthma. Methods 100 children with asthma in our hospital from March 2015 to October 2016 were selected as the subjects. They were randomly divided into two groups: the control group and the experimental group, with 50 cases in each group. The control group received routine treatment of bronchial asthma, and the experimental group received budesonide combined terbutaline aerosol inhalation treatment, and psychological intervention, pay attention to the patient's psychological state. The clinical efficacy, relative clinical symptoms, improvement time and length of hospital stay were compared between the 2 groups. Results The effective rate of the treatment group was 94%, which was significantly higher than that of the control group (72%), and the difference was statistically significant (P<0.05). The improvement time of dyspnea, wheezing and cough in control group was significantly higher than that in experimental group, while the control group was significantly longer than the experimental group, the difference was statistically significant (P<0.05). Conclusion Compared with conventional treatment,budesonide combined with terbutaline aerosol inhalation and psychological intervention in the treatment of children with asthma has better clinical efficacy and shorter clinical symptoms. It has the significance of further popularization and application.

Improvement Effect of Eucalyptol Enteric Soft Capsule on Lipopolysaccharide-induced Acute Lung Injury in Mice / 中国药房

OBJECTIVE:To investigate the improvement effect of Eucalyptol enteric soft capsule on mice with lipopolysaccha-ride(LPS)-induced acute lung injury(ALI). METHODS:60 mice were randomly divided into blank control group,model control group,Eucalyptol enteric soft capsule low-dose,medium-dose,high-dose groups(100,300,900 mg/kg),12 in each group. Mice in administration groups were intragastrically given relevant medicines,mice in blank control group and model control group were intragastrically given equal volume of normal saline(0.1 mL/10 g). After 2 h of administration,except for the blank control group, ALI was induced in other groups by atomized LPS. After 6 h of modeling,the mice were sacrificed,alveolar lavage fluid(BALF) and lung tissue were taken. Morphological changes of lung tissue were observed under microscope;number of total cells,neutro-phils in BALF were calculated by blood cell count plate and staining by wright-giemsa respectively. Total protein concentration in BALF supernatant was detected by BCA method;TNF-α,IL-6 contents in BALF supernatant were determined by enzyme-linked immunosorbent assay. RESULTS:Compared with blank control group,lung tissue of mice in model control group showed obvious pathological damage and severe pulmonary edema;number of total cells,neutrophils in BALF,total protein concentration and TNF-α,IL-6 contents in BALF supernatant were significantly increased(P0.05). CONCLUSIONS:High-dose Eucalyptol enteric soft capsule can obviously improve LPS-induced ALI of mice.

Progress of research on the minimally invasive treatment of bone metastases / 国际肿瘤学杂志

In recent years,minimally invasive techniques,such as percutaneous cementoplasty,percutaneous cryoablation,magnetic-resonance-guided focused ultrasound surgery,radiofrequency ablation,microwave ablation,radioactive particle implantation,transcatheter arterial embolization and irreversible electroporation et al,play more and more important roles in the treatments of bone metastasis.Compare with traditional therapies like radiotherapy,drugs and surgery,the better efficacy and security of minimally invasive techniques have been demonstrated by voluminous animal experiments and clinical trials.However,the clinical application of minimally invasive techniques have still some controversial issues.

A retrospective analysis of 68 cases of breast tubular carcinoma / 实用肿瘤学杂志

Objective To investigate the biological characteristics , therapy selection of tubular breast carcinoma.Relationship between axillary lymph node metastasis and other factors are analyzed retrospectively . Methods Tubular carcinoma patients were collected in our hospital from June ,1987 to March,2014.Paraffin tis-sues were re-checked again by pathology doctors and all patients were performed follow -up by telephone to e-valuate the prognosis .Results Sixty eight cases of tubular carcinoma of the breast were chosen .Axillary lymph node metastasis was closely related to tumor size and tumor grade in our research .In all patients ,only one patient was relapsed ,24 patients died of other diseases ,without distant metastasis or death of breast cancer .Conclusion Tubular breast carcinoma has a good prognosis with low recurrence rate .The treatment of tubular carcinoma is not quite reasonable .Preoperative core needle biopsy and surgery axillary staging should be paid more attention and breast conserving rate is still needed for improvement .

Effect of congrong powder preparation on erythrocyte parameter and index of blood rheology in rats / 中国中药杂志

<p><b>OBJECTIVE</b>To observe the effect of Congrong powder preparation on erythrocyte parameter and the index of blood rheology in healthy rats.</p><p><b>METHOD</b>The 50 rats were randomly divided into 5 groups ( physiological saline group, testosterone propionate group, large-dose administered group, moderate-dose administered group, small-dose administered group). Blood were taken to determine erythrocyte parameter and the index of blood rheology.</p><p><b>RESULT</b>Congrong powder preparation had no effect on erythrocyte parameter. There was an increase in whole blood viscosity, whole blood reduction viscosity, and in the erythrocyte rigidity index in the large-dose administered group.</p><p><b>CONCLUSION</b>Congrong powder can influence deformability and some related characters of erythrocytes.</p>

Research on the clinical application value of bone turnover markers in bone metastases from non-small cell lung cancer / 中国癌症杂志

Background and purpose:Bone metastases leads to the destruction of bones by changing the level of bone turnover markers.The purpose of this study was to assess the clinical application value of bone turnover markers in bone metastases for non-small cell lung cancer,which included the diagnosis and spread behavior of bone metastases.Methods:AKP,β-CTx,OST and BALP were measured in 76 NSCLC with bone metastases patients and 44 normal people.Results:The level ofAKP,β-CTx and BALP in patients with bone metastasis was significantly higher than in the subjects without bone metastases.There were significant correlations among the bone turnover markers.The levels of BALP and OST were significantly positively correlated with the extent of bone metastasis.Patients with high-levels of CTx and low-levels of BALP had a higher risk of pathologic fracture.Conclusion:In patients with bone metastases from NSCLC,bone turnover markers can help make diagnoses and evaluate severity of disease.It potentially has a wide range of uses in clinical practice.

Genus Gentianella Moench:A Phytochemical and Ethnopharmacological Review / 中草药·英文版

The plants in genus Gentianella Moench (Gentianaceae) which comprised approximately 250 species, are mainly distributed in temperate regions of the world.Many Gentianella plants are intensely bitter and employed in traditional medicine to stimulate appetite, treat disorders of the gallbladder, and treat fever like the other bitter gentians in various regions of the world.Some species exhibit other remarkable therapeutic effects in the treatments of obesity,diabetes, and heart diseases.Eleven iridoids, twenty-eight xanthones, three C-glucoflavonoids, and eight other compounds have been isolated from the genus.Most of these compounds are associated with antimicrobial,anti-inflammatory, anti-oxidant, hypoglycemic, and antitumor activities, which provide an empirical base for the traditional utilization of the plants in genus Gentinella Moench.

Association study of lipoprotein lipase Ser447Stop polymorphisms with acute ischemic stroke / 中华神经科杂志

Objective To investigate the genetic association between polymorphisms of Ser447Stop in lipoprotein lipase (LPL) gene and ischemic stroke. MethodsA case-control study was performed in 563 acute ischemic stroke patients and 320 controls. LPL Ser447Stop genotypes in the subjects were detected by polymerase chain reaction and restriction fragment length polymorphism assay. The frequencies of the alleles in each group were statistically analyzed with Student t-test. ResultsNo significant difference was found in the frequency of G allele of LPL Ser447Stop polymorphism between the case and the control. When subjects were divided into 2 subgroups of cerebral thrombosis infarction and lacunar infarction, the frequency of G allele was significantly higher in the cerebral thrombosis infarction group (9. 7％ ) than that in the control (6. 6％, χ2= 3. 99,P = 0. 045 ), and an increased risk for thrombosis infarction was suggested in the G allele ( OR = 1. 510, 95％ CI 1. 012--2. 261 ). ConclusionThe G allele in polyim Ser447Stop in LPL may be associated with increased risk of cerebral thrombosis infarction.

Comparison of curative effect of paracetamol and indomethaein suppository in eaneerons febrile / 中国基层医药

Objective To observe the curative effect of paracetamol and indomethacin suppository in cancer- ous febrile. Methods 108 patients of lung cancer with fever were divided into.two groups,the treatment group of 54 cases and the control group of 54 cases, administered with paracetamol and indomethacin suppository respectively. Results After the two groups took medicine, the difference in defervesceing was significant, with statistics signifi- cance( P < 0.05). Conclusion Indomethacin suppository shows better function of defervesceing than paracetamol.

Ectopic parathyroid gland hyperplasia in the pyriform sinus / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To explore the diagnosis and treatment of the ectopic parathyroid gland in the pyriform sinus.@*METHOD@#Retrospectively analysis of 1 case with ectopic parathyroid gland in the pyriform sinus and retrospectively review the past literatures.@*RESULT@#The cases with the ectopic parathyroid gland in the pyriform sinus reported in the past literatures included: 2 with parathyroid gland tissues, 3 with hyperplasia, the other 1 with adenoma. The case reported by us was with adenoma.@*CONCLUSION@#The ectopic parathyroid gland hyperplasia in the pyriform sinus is rarely reported before and it usually causes misdiagnosis. Better knowledge of the different position of the ectopic parathyroid gland hyperplasia in the pyriform sinus will help diagnosing and treating it.

Comparison of the five models on experimental hyperlipidemia rats / 中国药理学通报

Aim To select the ideal experimental rats model for research on prevention and treatment of Hyperlipidemia.Methods Five prescriptions on experimental hyperlipidemia-rats were selected and emulsion was made.At 10、20、30 d blood samples were taken from ocular orbit and content of CHO、 LDL、 HDL 、TG in the serum were measured.Results Four of the five prescriptions could lead to the disorder of lipid metabolism at different levels.Conclusion An ideal experimental rats model of hyperlipidemia can be made if bile salt and propylthiouracil are conbined to add to the fat emulsion of lard and cholesterol.

Microarray expression analysis identified several key protein candidates as the potential mediators of total flavones of choerospondias axillaries fructus on myocardial protection / 中国药理学通报

Aim To study the molecular basis of protection on myocardial ischemic injuries of total flavones of choerospondias axiaris fructus(TFC). Methods The microarray analysis for the protein expression in myocardium provide a strong tool to explore the key protein candidates involved in the pathogenesis of ischemic injury.Surface enhanced laser desorption/ionization(SELDI) mass spectrometry with protein chip IMAC3,SAX2 and NP20 was used to compare the differentially expressed protein in TFC-treated and untreated ischemic myocardium in rats and the results were analysized with Proteinchip Software 3.0.2.Results Seven differentially expressed proteins were indentified in TFC treated myocardium.These differential effects correlated with the expression of five downregulated proteins and two upregulated proteins,and four of them were discovered on the IMAC3 chip and one of them was discovered on the SAX2 chip.Conclusions The myocardial protection of TFC may be mediated by the differential expression of these proteins which could be the key protein candidates for further investigation.

Different sampling method affects the voice assessment results for the patient with vocal polyp / 临床耳鼻咽喉头颈外科杂志

In order to definitude the influence caused by the different sampling in voice assessment.Method:We comparing the results acquired by total section and subsection sampling.Result:The results acquired by subsection tended to normal more than those acquired by total section. Conclusion:Subsection sampling voice assessment might conceal the drgree of the disease state of patients

Effect of Toutongling Capsule on Cerebral Vessels and Blood Viscosity / 广州中医药大学学报

Toutongling Capsule is a Chinese herbal preparation developing from an ancient formula processed by modern technology. Previous clinical studies have shown that Toutongling Capsule exerts a good effect on vascular headache, tonic headache and traumatic headache. To further explore its pharmacological mechanism, the effect of Toutongling Capsule on cerebral vessels and blood viscosity in experimental dogs was observed. The results showed that Toutongling Capsule can decrease cerebral vascular resistance obviously and increase cerebral blood flow, with a good dose-effect relationship. As compared with Yangjiao Granule, Toutongling Capsule possesses a similar effect on blood viscosity but stronger effect on dilatation of cerebral vessels and increase of cerebral blood flow. Both Toutongling Capsule and Yangjiao Granule have no effect on blood pressure and ECG.

Skills using model BT87-3 experimental intracorporeal thrombosis surveyor and precautions / 中国药理学通报

Model BT87-3 experimental intracorporeal thrombosis surveyor is an instrument used to determine animal intracorporeal thrombosis. It is now being used in more and more medical and pharmaceutical schools as well as research academies and institutes,with good effects.We have used it for many years and summed up a set of skills of use and precautions for people of the same profession.

Study of In Vitro Inhibition Effect of Pomegranate Rind on H.pylori / 昆明医科大学学报

Objective To discuss in vitro the inhibition effect of Pomegranate Rind on H.pylori metronidazole resistant strains and susceptible strains.Methods The Agar Dilution Method detects the minimal inhibitory concentration(MIC) of the water extract of Pomegranate Rind on H.pylori metronidazole resistant strains and susceptible strains,MIC_(50)、MIC_(75)、MIC_(90) were also calculated.Results MIC of Pomegranate Rind on H.pylori was in a range of 7.8125 to 500mg/mL;MIC_(50) of H.pylori metronidazole resistant strains and susceptible strains on Pomegranate Rind was 29.9mg/mL and 28.0mg/mL respectively,MIC_(75) was 65.1mg/mL and 59.1mg/mL respectively,MIC_(90) was 131.1mg/mL and 115.9mg/mL respectively.The susceptibility of H.pylori metronidazole resistant strains and susceptible strains on Pomegranate Rind has no statistical difference(relative median potential= 1.072,95% credible range from 0.763 to 1.513).Conclusion H.pylori metronidazole resistant strains and susceptible strains was susceptible to Pomegranate Rind.