ABSTRACT
We describe two cases of pulmonary arterial hypertension (PAH) that occurred under dasatinib treatment and were resolved after dasatinib discontinuation. Two patients with chronic phase chronic myeloid leukemia (CML) were switched to dasatinib therapy because of hematological progress while receiving imatinib. These patients had New York Heart Association (NYHA) functional class II dyspnea with elevated right ventricular systolic pressure (RVSP), which progressed under dasatinib treatment. After dasatinib treatment was discontinued, subjective symptoms were improved to NYHA functional class I and the follow-up transthoracic Doppler echocardiography showed improved RVSP. Treatment with an alternate tyrosine kinase inhibitor was initiated and had been continued without development of dyspnea or elevation of RVSP. This report suggests that dasatinib can cause the reversible PAH, therefore, routine cardiopulmonary evaluation before and during treatment with dasatinib may be needed in CML patients with clinical manifestations.
Subject(s)
Humans , Blood Pressure , Dyspnea , Echocardiography, Doppler , Follow-Up Studies , Heart , Hypertension , Leukemia, Myelogenous, Chronic, BCR-ABL Positive , Protein-Tyrosine KinasesABSTRACT
PURPOSE: This study was done to investigate the relationship between metacognition, learning flow, and problem solving ability in simulation learning of nursing students and to identify the factors influencing problem solving ability. METHODS: The study sample was 136 nursing students. Data were collected from September to November, 2012 using a structured questionnaire on metacognition, learning flow and problem solving ability. Descriptive statistics, Pearson correlation and stepwise multiple regression analysis were used with the SPSS win 20.0 program to analyze the data. RESULTS: There were significant positive correlations between metacognition, learning flow and problem solving ability. Learning flow was a significant factor affecting problem solving ability. These variables accounted for 33% of variance. CONCLUSION: These results suggest that simulation learning has a positive effect on nursing students' learning outcomes.
Subject(s)
Humans , Cognition , Learning , Patient Simulation , Problem Solving , Surveys and Questionnaires , Students, NursingABSTRACT
The purpose of this study is to develope new dental color-space system. Twelve kinds of dental composites and one kind of dental porcelain were used in this study. Disk samples (15 mm in diameter, 4 mm in thickness) of used materials were made and sample's CIE L*a*b* value was measured by Spectrocolorimeter (MiniScan XE plus, Model 4000S, diffuse/8degrees viewing mode, 14.3 mm Port diameters, Hunter Lab. USA). The range of measured color distribution was analyzed. All the data were applied in the form of T### which is expression unit in CNU Cons Dental Color Chart. The value of L* lies between 80.40 and 52.70. The value of a* are between 10.60 and 3.60 and b* are between 28.40 and 2.21. The average value of L* is 67.40, and median value is 67.30. The value of a* are 2.89 and 2.91 respectively. And for the b*, 14.30 and 13.90 were obtained. The data were converted to T### that is the unit count system in CNU-Cons Dental Color Chart. The value of L* is converted in the first digit of the numbering system. Each unit is 2.0 measured values. The second digit is the value of a* and is converted new number by 1.0 measured value. For the third digit b* is replaced and it is 2.0 measured unit apart. T555 was set to the value of L* ranging from 66.0 to 68.0, value of a* ranging from 3 to 4 and b* value ranging from 14 to 16.