ABSTRACT
Cardiac pacemaker is a critical therapeutic option for patients with bradyarrhythmias,but traditional wired pacemakers have many shortcomings.Current efforts to develop leadless cardiac pacemakers(LCP)have two primary goals,namely to reduce lead-associated complications and to avoid surgical scar associated with placement. The present article reviewed related researches on LCP in recent years,and explored the limitations and future de-velopment of different LCP currently under study.
ABSTRACT
Nonalcoholic and alcoholic rabbit models of fatty liver were established by feeding on high-fat diet and alcohol, respectively, and fatty liver stiffness at different pathological stages was assessed with real-time shear-wave elastography (SWE), so as to investigate the fibrosis process during the development of fatty liver. The fatty liver stiffness of rabbit in nonalcoholic and alcoholic groups was higher than that in the control group, and that in alcohol group was higher than that in the nonalcoholic group (P<0.01). The elasticity modulus of liver in fatty liver rabbits of nonalcoholic and alcoholic groups showed a positive correlation with progression of liver fibrosis (P<0.01). Real-time SWE, as a noninvasive diagnostic method, can objectively reflect the liver stiffness change and progression of liver fibrosis during the development of fatty liver.
Subject(s)
Animals , Male , Rabbits , Elasticity , Elasticity Imaging Techniques , Methods , Fatty Liver, Alcoholic , Diagnostic Imaging , Liver Cirrhosis , Diagnostic Imaging , Non-alcoholic Fatty Liver Disease , Diagnostic ImagingABSTRACT
Nonalcoholic and alcoholic rabbit models of fatty liver were established by feeding on high-fat diet and alcohol, respectively, and fatty liver stiffness at different pathological stages was assessed with real-time shear-wave elastography (SWE), so as to investigate the fibrosis process during the development of fatty liver. The fatty liver stiffness of rabbit in nonalcoholic and alcoholic groups was higher than that in the control group, and that in alcohol group was higher than that in the nonalcoholic group (P<0.01). The elasticity modulus of liver in fatty liver rabbits of nonalcoholic and alcoholic groups showed a positive correlation with progression of liver fibrosis (P<0.01). Real-time SWE, as a noninvasive diagnostic method, can objectively reflect the liver stiffness change and progression of liver fibrosis during the development of fatty liver.