ABSTRACT
Objective To explore the distribution proportion of peripheral blood HLA-DR-CD33+ CD14-CD11b+ myeloidderived suppressor cells (MDSC) in the patients with nasopharyngeal carcinoma(NPC) to provide a beneficial guidance for NPC immunotherapy.Methods Forty-five NPC patients and 20 healthy volunteers as the healthy control group were selected.The peripheral blood sample was collected before the first time chemotherapy and on 7 d after the second cycle induction chemotherapy,meanwhile the peripheral blood sample was collected in the healthy control group;then HLA-DR-CD33+ CD14-CD11b+ MDSC were detected by the flow cytometry.Results The peripheral blood MDSC ratio of NPC patients was significantly higher than that of healthy control group(P＜0.05).With the NPC stage Ⅱ,Ⅲ and Ⅳ increase,the peripheral blood MDSC ratio was gradually increased (P＜0.05).The MDSC ratio of NPC patients with three different pathological types of keratin type squamous carcinoma,differentiated and undifferentiated type non-keratin type squamous carcinoma was significant higher than that of healthy control group(P＜0.05).The peripheral blood MDSC ration also had statistical difference among the NPC patients with 3 kinds of different pathological type(P＜0.05).The peripheral blood MDSC ratio in NPC patients with different stages was significantly decreased after 2-cycle induction chemotherapy (P ＜ 0.05),but its ratio level was still higher than that of the healthy control group.Conclusion The peripheral blood HLA-DR-CD33+ CD14-CD11b+ MDSC ratio in the NPC patients is significantly increased,suggesting that which may be related with NPC immune escape and is worth further study.