ABSTRACT
Objective To explore the correlation between quantitative parameters of dynamic enhanced magnetic resonance imaging (DCE-MRI) and Dukes stage,lymph node metastasis,tumor differentiation degree and molecular biological indicators [Ki67 and human epidermal growth factor receptor 2 (CerbB-2)] of rectal cancer.Methods This study was a prospective study.From October 2014 to October 2017,168 cases of rectal cancer patients were selected as the research objects.DCE-MRI was performed preoperatively to obtain the quantitative parameter values of region of interest (ROI) [apparent diffusion coefficient (ADC) Ktrans,Ve,and Kep] in tumor site.The expression of Ki67 and CerbB-2 were detected by immunohistochemical.Correlations of DCE-MRI quantitative parameter values and rectal cancer Dukes staging,lymph node metastasis,tumor differentiation degree to Ki67 and CerbB-2 expression level were analysised.Results With the increase of tumor differentiation,ADCmean was increasing,while Ktrans and Ve showed a downward trend,with significant difference (P ＜ 0.05).Among them,Ktrans and Ve in the high-differentiation group and the medium-differentiation group were significantly lower than those in the low-differentiation group (P ＜ 0.05),while there was no statistical significance between the high-differentiation group and the medium-differentiation group (P ＞ 0.05).The ADC was statistically significant between different groups (P ＜ 0.05),while Kep was not statistically significant (P ＞ 0.05).The ADCmean of lymph node metastasis group was significantly lower than that of no lymph node metastasis group (P ＜0.001),while Ktrans,Ve and Kep were significantly higher than that of no lymph node metastasis group (P ＜0.001).With the increase of Dukes staging in rectal cancer,ADCmean was decreasing and Ktrans was increasing,with statistically significant difference (P ＜0.001);among which the ADCmean of Dukes A and B was significantly higher than that of Dukes C and D (P ＜ 0.05),and Ktrans was significantly lower than that of Dukes C and D (P ＜ 0.05).Ktrans and Kep were increased with the increased expression levels of Ki67 and CerbB-2,and the difference between Ktrans and Kep was statistically significant (P ＜ 0.05).The ADCmean decreased with the increase of Ki67 and CerbB-2 expression level,and the difference was statistically significant (P ＜ 0.05).Conclusions DCE-MRI quantitatively participates can reflect the biological behavior of rectal cancer,and can be used to evaluate the prognosis of tumors and guide the clinical selection of more appropriate treatment options.
ABSTRACT
Objective@#To explore the correlation between quantitative parameters of dynamic enhanced magnetic resonance imaging (DCE-MRI) and Dukes stage, lymph node metastasis, tumor differentiation degree and molecular biological indicators [Ki67 and human epidermal growth factor receptor 2 (CerbB-2)] of rectal cancer.@*Methods@#This study was a prospective study. From October 2014 to October 2017, 168 cases of rectal cancer patients were selected as the research objects. DCE-MRI was performed preoperatively to obtain the quantitative parameter values of region of interest (ROI) [apparent diffusion coefficient (ADC)mean, Ktrans, Ve, and Kep] in tumor site. The expression of Ki67 and CerbB-2 were detected by immunohistochemical. Correlations of DCE-MRI quantitative parameter values and rectal cancer Dukes staging, lymph node metastasis, tumor differentiation degree to Ki67 and CerbB-2 expression level were analysised.@*Results@#With the increase of tumor differentiation, ADCmean was increasing, while Ktrans and Ve showed a downward trend, with significant difference (P<0.05). Among them, Ktrans and Ve in the high-differentiation group and the medium-differentiation group were significantly lower than those in the low-differentiation group (P<0.05), while there was no statistical significance between the high-differentiation group and the medium-differentiation group (P>0.05). The ADCmean was statistically significant between different groups (P<0.05), while Kep was not statistically significant (P>0.05). The ADCmean of lymph node metastasis group was significantly lower than that of no lymph node metastasis group (P<0.001), while Ktrans, Ve and Kep were significantly higher than that of no lymph node metastasis group (P<0.001). With the increase of Dukes staging in rectal cancer, ADCmean was decreasing and Ktrans was increasing, with statistically significant difference (P<0.001); among which the ADCmean of Dukes A and B was significantly higher than that of Dukes C and D (P<0.05), and Ktrans was significantly lower than that of Dukes C and D (P<0.05). Ktrans and Kep were increased with the increased expression levels of Ki67 and CerbB-2, and the difference between Ktrans and Kep was statistically significant (P<0.05). The ADCmean decreased with the increase of Ki67 and CerbB-2 expression level, and the difference was statistically significant (P<0.05).@*Conclusions@#DCE-MRI quantitatively participates can reflect the biological behavior of rectal cancer, and can be used to evaluate the prognosis of tumors and guide the clinical selection of more appropriate treatment options.
ABSTRACT
Objective To explore the method and evaluate the effect of locking compression plate (LCP)fixation of intraarticular unstable distal radial fractures.Methods Thirty patients with intraarficular unstable distal radial fractures were treated with LCP.According to AO/ASIF classification,there were 6 cases of type B2 fractures,7 cases of type B3,7 cases of type C1,8 cases of type C2,2 cases of type C3.Results After 6 to 24 months(average 12 months)following up,there were 15 cases graded as excellent,10 eases as good,3 cases as fair,and 2 cases as poor,according to X ray and wrist function assessment.The overall satisfaction rate was 83.3％.Conclusion Volar LCP fixation is a safe and effective treatment for intraarticular unstable distal radial fractures.It could effectively prevent loss of reduction,avoid tendon irritation and other complications if selecting implant angle for locking screw according to the specific intraoperative circumstances.