Lentiviral vectors and advance in its application / 生物医学工程学杂志

Lentiviral vectors (Lv), known as holding lots of virtues (e.g. transfection to the dividing or non-dividing cells;large capacity of transfer gene fragments; long-term expression transfer genes; and low rate of immunological response) has come to be one of the hot-spots in gene therapy research. In this paper, taking the Lv derived from HIV-1 for example, we review the characteristics of frame, the developments and the advances in application of Lv.