Prognostic factors analysis of nasal NK/T cell lymphoma / 中国耳鼻咽喉头颈外科

OBJECTIVE To investigate the prognosis of nasal NK/T cell lymphoma.METHODS The clinical data of 112 patients with a primary diagnosis of nasal NK/T cell lymphoma treated at the First Hospital of Zhengzhou University between January 2010 and June 2017 were studied.The association between clinical parameters and survival rate was evaluated by Kaplan-Meier method and Cox regression model.RESULTS The 1-,3-,5-year overall survival were 92％,72％ and 54％ respectively.Single factor analysis displayed that age,gender,the level of albumin,the expression level of Ki-67,treatment model,complete response rate to the primary treatment and the interval between symptom onset to diagnosis were related to the prognosis factors.Multivariate analysis showed that the interval of first time of symptom onset to the time of diagnosis and the positive rate of Ki-67 more than 50％ were the independent risk factors for the prognosis of nasal NK/T lymphoma.CONCLUSION The interval of symptom onset to the time of diagnosis and the positive rate of Ki-67 may be independent prognostic factors for NK/T cell lymphoma.

The expression and role of MIF, NF-κB and IL-1β in nasal polyps / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To investigate the expression of MIF, NF-κB p65 and IL-1β in the tissue of nasal polyps and normal inferior turbinate, to analyze their relevance, and to explore their role in nasal polyps.@*METHOD@#The infiltrating results of EOS and others inflammatory cells in 48 cases diagnosed as nasal polyps (nasal polyps group) were detected by HE staining, and the expression of MIF, NF-κB p65 and IL-1β were investigated by immunohistochemistry. Twenty-one patients who were performed septoplasty orthotics were included as the control group; the VAS and Lund-Kennedy score were used to evaluate the degree of nasal polyps in patients and the correlation analysis was conducted between the disease severity and the expression levels of this three factors.@*RESULT@#(1) The infiltrating results of EOS and the expression level of MIF, NF-κB p65, IL-1β in nasal polyps group are obviously higher than these in the control group (P 0.05).@*CONCLUSION@#MIF, NF-κB p65 and IL-1β may promote the development of the nasal polyps, and there may exist the IL-1β--NF-κB--MIF approach in nasal polyps; MIF and NF-κB may participate in maintaining physiological function of inferior turbinate and have relations with the lightest sustained inflammation of inferior turbinate. The MIF and NF-κB p65 nuclear activation rate can be used as a standard of the nasal polyp severity and the judgement prognosis.

The perioperative observation under endoscopic sinus surgery with asthma / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#Aimed to discuss the perioperative treatment of the patient with asthma under endoscopic sinus surgery, to reduce the complications, adverse events and improve cure rate.@*METHOD@#One hundred and fifty-two patients with asthma under nasal endoscopic surgery were analyzed retrospectively.@*RESULT@#After specification of perioperative treatment, all patients with good control of asthma were in good condition before surgery. One hundred and sixteen patients were safely backed to ward after surgery. There were 13 cases had asthma attack of different degrees. The other 35 patients were send to ICU for observation of 24 to 48 h. One case had an acute attack after returned from ICU. One patient had instantly attacks of asthma after extubation. All patients improved after treatment,and recovered well after 1 year's follow-up.@*CONCLUSION@#We should pay more attention to the close relationship of CRS and asthma, standardize the perioperative treatment, master the principles of management of acute attack of asthma. As long as to make sufficient perioperative preparation, the nasal endoscopic surgery with asthma is safe, and it can have good efficacy.

A case of giant cavernous hemangioma of the nasal septum / 临床耳鼻咽喉头颈外科杂志

To report a case of an adult male with a huge cavernous hemangioma arising from the nasal septum, and the lesion was widely spread to hard palate, sphenoid sinus, ethmoid sinus and right maxillary sinus. After giving embolization, it was completely excised via transnasal endoscopic approach and lateral rhinotomy, histologic examination reported cavernous hemangioma. There was no recurrence at 1 year's follow-up.

Expression and correlational research of mTOR and 4EBP1 in laryngeal carcinoma / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#This study aimed to explore the expression and their correlation of mammalian target of rapamycin (mTOR) and EIF4E binding protein1 (4EBP1) in laryngeal squamous cell carcinoma (LSCC).@*METHOD@#MTOR and 4EBP1 expression was studied using immunohistochemical methods in LSCC tissues of 77 cases and adjacent tissues of 18 cases,and then the relationship of their expression and clinical pathological factors were analyzed.@*RESULT@#The positive expression rates of mTOR and 4EBP1 were 54.5% and 48.1% in laryngeal carcinoma, which was significantly higher than those in para-carcinoma (P 0.05). There was significant positive correlation between the expression level of mTOR and 4EBP1 in LSCC (P < 0.05).@*CONCLUSION@#(1) The high expression of mTOR and 4EBP1 is closely related with clinicopathology and lymph node metastases. It may play an important role in the development and progression of laryngeal carcinoma. (2) The positive correlation on expression level of mTOR and 4EBP1 in LSCC tissue shows that it has clinical significance on clinical therapy and prognosis.

Inflammatory myofibroblastic tumor in the maxillary sinus: a case report and review of literature / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To investigate the clinical feature, diagnostic and therapeutic methods of inflammatory myofibroblastic tumor(IMT).@*METHOD@#One case of IMT was reported and the relevant literatures were reviewed.@*RESULT@#The computed tomography scan showed irregular soft tissue density shade and aggressive bone destruction with unclear boundary. Pathological findings showed variable numbers of inflammatory cells and myofibroblastic spindle cells. Tumor cells were immunoreactive for vimentin and smooth muscle actin, but negative for desmin et al.@*CONCLUSION@#IMT of the maxillary sinus is very rare. The diagnosis of IMT base on histopathology and immunohistochemistry. The genesis and development of IMT result from chromosomal translocations that often cause an overexpression of anaplastic lymphoma kinase. IMT are clinical and pathological distinct entities and its biological behavior is still uncertain.

Isolated sphenoid sinus disease: a clinical analysis of 159 cases / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#Aimed to observe and analyse the diagnostic and therapeutic methods of the isolated sphenoid sinus disease, achieve earlier diagnosis and timelier intervention for this easily neglected disease and decrease the occurrence of misdiagnoses.@*METHOD@#A retrospective study was conducted in 159 patients with isolated sphenoid sinus disease.@*RESULT@#Headache was the most common presenting symptom (79.87%,127/159). Among the 159 cases, 60 (37.74%) had mucocele, 44 (27.67%) isolated sphenoiditis, 31 (19.50%) fungal sinusitis, 5 (3.14%) polyp, 3 (1.89%) fibrous dysplasia, 2 (1.26%) inverted papilloma, 3 (1.89%) chordoma, 3 (1.89%) squamous carcinoma, 3 (1.89%) malignant lymphoma, 2 (1.26%) neuroendocrine carcinoma, 2 (1.26%) olfactory neuroblastoma, and 1 (0.63%) malignant fibrohistiocytoma. A follow-up of 10 months to 4 years post-surgery showed good prognosis in most of the patients who underwent surgical therapy.@*CONCLUSION@#The sphenoid sinus disease is often vague and nonspecific in its clinical presentation. The most common clinical symptom is headache, followed by vision changes. Endoscopic sphenoidotomy is the primary therapy for isolated sphenoid sinus disease.

Expression of hypoxia inducible factor-1alpha and BNIP3 in human laryngeal carcinoma and their relationship / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To investigate the expression of Hypoxia inducible factor-1alpha (HIF-1alpha)and the Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) in human laryngeal carcinoma and their relationship.@*METHOD@#The expression of HIF-1ALPHA and BNIP3 were detected by SP immunohistochemical method in 45 cases with laryngeal carcinoma tissues and 12 adjacent normal laryngeal tissue.@*RESULT@#The expression of HIF-1alpha and BNIP3 were mainly in cytoplasm and nucleus. Their expression was higher in laryngeal tissue than in adjacent normal laryngeal tissue (P < 0.05). The expression of HIF 1alpha was positively related to that of BNIP3 in laryngeal carcinoma tissues (P < 0.05).@*CONCLUSION@#The high expression of HIF-1alpha and BNIP3 were closely related in laryngeal carcinomas, both of them played important role in the carcinogenesis and development of laryngeal carcinoma. HIF-1alpha might induce the expression of BNIP3. HIF-1alpha and BNIP3 might to be two potential therapeutic targets in laryngeal squamous, cell carcinomas.