ABSTRACT
Objective:To investigate the role of serum RGS2 protein,Ang Ⅱ and AT1R in the Pathogenesis of Preeclampsia and it's impact on the severity of the disease.Methods:Totally 50 patients with PE collected from Shenzhen Maternity and Child Healthcare Hospital,Southern Medical University during October 2015-September 2016 were recruited as PE group(PE with FGR group 17 cases and PE without FGR group 33 cases),40 cases of healthy pregnant women were collected as the control group.ELISA was used to detect the serum RGS2 protein,Ang Ⅱ and AT1R levels.he differences between the groups were compared.Logistic regression was used to analyze the correlation between the three indexes and the severity of PE.Results:①In PE group plasma RGS2 protein,Ang Ⅱ,AT1R levels and systolic blood pressure,diastolic blood pressure,sampling gestational age,maternal gestational age,neonatal birth weight were higher than those in control group(P ＜ 0.05);There was no significant difference on RGS2 protein level,systolic blood pressure and diastolic blood pressure between PE with FGR group and PE without FGR group(P＞0.05),There was significant difference on the Ang Ⅱ,AT1R level and newborn weight(P ＜ 0.05).②Logistic regression analysis showed that RGS2 、Ang Ⅱ and AT1R were the independent risk factors of PE.(the crude odds ratio of RGS2,Ang Ⅱ and AT1R were ＞ 1,P ＜ 0.05.After adjust the sampling of gestational age the OR values were ＞ 1,P ＜0.05.After adjust the other two indicators the OR values were ＞ 1,P ＜0.05,except for Ang Ⅱ.).③RGS2 protein,Ang Ⅱ,AT1R levels were positively correlated with PE,systolic and diastolic blood pressure(P ＜ 0.05).Ang Ⅱ,AT1R levels were negatively correlated with neonatal birth weight (P ＜ 0.05).RGS2 was not related with neonatal birth weight (P ＞ 0.05).Conclusions:Plasma RGS2 protein,Ang Ⅱ and AT1R may be associated with the pathogenesis of PE and Ang Ⅱ and AT1R may be associated with the severity of the disease.
ABSTRACT
Objective To explore the impact of psychological intervention on response and defense style of AIDS patients.Methods 88 AIDS patients were selected and investigated using medical response (MCMQ) and defense style (DSQ) survey,the scores before and after psychological intervention were compared.Results Mental health problems included fear,afraid,pessimism and worry,the response style included face,avoid,yield.Scores showed significant difference before and after intervention among patients choosing immature-type,mature-type and cover-up defense styles.Conclusions Psychological intervention can promote rehabilitation and health of AIDS patients as well as improve their life quality and prevent disease relapse.