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Objective To investigate the safety and clinical efficacies of microvascular decompression(MVD) on cranial neuropathy such as trigeminal neuralgia (TN),hemifacial spasm (HFS)and glossopharyngeal neuralgia(GN)in elderly patients.Methods Clinical data of 72 patients aged 70 years and over diagnosed as cranial neuropathy and undergoing microvascular decompression in our department from January 2015 to August 2017 were retrospectively analyzed.The curative effect and complications were analyzed after treatment.Results All patients successfully underwent MVD under general anesthesia.The facial pain completely disappeared or was significantly improved in 85.7 ％ (30/35)of TN patients one year after operation.The intermittent tonic contractions of the facial muscles were completely disappeared in 94.3％ (33/35)of HFS patients.Clinical symptoms were completely disappeared in 2 patients with GN,4 patients with TN and HFS and 1 patients with TN and GN.Conclusions The surgery goes well and the patients have good postoperative recovery,with no severe complications such as intracranial hematoma,infarction,cerebrospinal fluid leakage,acute hydrocephalus and death.After an adequate preoperative evaluation,MVD is safe and effective with a few complications.It can significantly improve the quality of life in elderly patients with trigeminal neuralgia,hemifacial spasm,and glossopharyngeal neuralgia.
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Objective:To establish a specialized detection method for quinolone drugs illegally added in health foods and Chinese traditional patent medicines. Methods: LC-MS/MS was used to simultaneously screen pipemidic acid, norfloxacin, ciprofloxacin, lomefloxacin, enoxacin, fleroxacin, pefloxacin, sparfloxacin, gatifloxacin and ofloxacinan in health foods and Chinese traditional patent medicines. Qualitative and quantitative analysis and methodology validation were studied as well. Results:Under the conditions of the analysis method, the 10 quinolone drugs added illegally obtained a good separation on a chromatographic column. With the two grade mass spectrum for the qualitative analysis and the peak area of multiple reactions monitoring mode for the quantitative calculation, the method was specific and sophisticated. The recovery and linear relationship met the demand of screening. Conclusion:The method is simple and accurate in the detection of quinolone drugs in health food and Chinese traditional patent medicines.
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Objective To observe the therapeutic effect of acupuncture for treatment of malignant tumor patients with symptoms of digestive system.Methods We carried out a cohort study and enrolled 92 malignant tumor patients hospitalized at Yantai cancer hospital from July 2008 to Jun 2009.They were randomly divided into three groups by the random number table with the ratio of 1 ∶ 1 ∶ 1.The three groups were pattern differentiation acupuncture group that including excess and deficiency syndromes,non pattern differentiation acupuncture group and the western medicine control group.Patients in pattern differentiation acupuncture group accept different acupuncture treatment with different acupoints according to their pattern.Patients in non pattern differentiation acupuncture group only accept acupuncture treatment with fixed acupoints.All patients in the two groups accepted acupuncture treatment one times per day,seven days is a course of treatment.Western medicine control group get routine chemotherapy including CTX,ADM,VCR,VP-16,PDD,MTX 5-FU,and symptomatic and support treatment were added according to the patients symptoms.Efficacy of all groups were evaluated and compared after one course of treatment.Results (1) Comparison of symptom change scores:①Inner group comparison:Patients' symptoms were significantly improved after treatment in pattern differentiation acupuncture group and non pattern differentiation acupuncture group (P＜0.05); The difference of patients' symptoms before and after treatment didn't show statistical significance in western medicine control group differences (P＜0.05).② Comparison among groups:Compared with western medicine control group,the difference among pattern differentiation acupuncture group and non pattern differentiation acupuncture group were statistically significant after treatment (t=2.212,1.989,P＜0.05),the difference between pattern differentiation acupuncture group and non pattern differentiation acupuncture group didn't show statistically significant (t=1.548,P＞0.05).(2) Improvement of digestive system symptoms:Compared with western medicine control group,the difference among pattern differentiation acupuncture group and non pattern differentiation acupuncture group was statistically significant after treatment (x2=15.28,13.45,P＜0.05),the difference between pattern differentiation acupuncture group and non pattern differentiation acupuncture group didn't show statistically significant (x2=9.81,P＞0.05).Conclusion Acupuncture treatment can improve the symptoms of digestive system of malignant tumor patients.
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@#Objective To screen the optimum conditions carrying murine melanoma B16 cells in spaceflights without cares.MethodsMurine melanoma cells were cultured on micocarriers and grouped depending on cells concentration, serum concentration, microcarrier number and temperature.After 33 days, B16 cells were stained by Giemsa, observed with phase-contrast microscope and counted for surviving percentage.ResultsThe optimum conditions,in which the surviving percentages were 8% and 10%, were obtained in the experiments.B16 cells were carried in the 20th recoverable satellite orbiting 18 days under the optimum conditions. After recovering, 110 strain monocloned cells were survived and the surviving percentage was 1.1%.ConclusionThe optimum conditions carrying murine melanoma B16 cells in spaceflights without cares seems to be obtained,and it did improve the surviving time and percentage of cells in spaceflights without cares.
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Objective:To determine the contents of paraceltamol and caffeine in New compouad Folium Isatidis Tablets simultaneously by HPLC. Methods:The determination was carried out with C 18 chemical bonded silica gel as a solid phase, methanol-water (25∶75) as a mobile phase and UV deterction wavelength at 215 nm. Results: The average recovenies of the added sample were 99.6%( RSD=0.67, n=5) for paracetamol and 99.3%(RSD=0.58, n=5) for caffine, There was a good linear relationship between the concentration and absorption area value in the rang of 1.6?g～6.4?g for paractamol or 0.16?g～0.64?g for caffeine.Conclusions: The method is simple, quick and accurate.