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Objective To investigate whether a 3D printed model of the contrlateral healthy distal radius, especially its articular accuracy, helps anatomical reduction and precise reconstruction of the fractured distal radius. Methods The CT data of bilateral radii were collected from 15 normal volunteers ( 11 males and 4 females with an average age of 22. 8 years ) between November and December 2016. After 3D reconstruction of the bilateral distal 1/3 radii, solid 3D models of left radius were mirrored and generated by 3D printing. The data of right radii ( reference group ) were compared with the data of the solid 3D models of left radius acquired through a 3D scanner ( test group ) using deviation analysis. Results The maximum volume difference between the 3D printed model and the contralateral radius was 6. 86％. The average volume of the reference group was 19, 165. 82 ± 3, 250. 50 mm3 and that of the test group 19, 310. 65 ± 3, 305. 15 mm3, showing no statistically significant difference between the 2 groups ( t= -0. 941, P=0. 363 ) . The maximum surface area difference was 3. 84％ between the 2 groups. The average surface area of the reference group was 5, 075. 80 ± 549. 34 mm2 and that of the test group 5, 139. 43 ± 572. 48 mm2, showing a signifi-cant difference ( t= -2. 451, P=0. 028 ) . The 3D deviation analysis showed a mean positive deviation of 0. 37 ± 0. 10 mm and a mean negative deviation of 0. 30 ± 0. 07 mm. The maximum mean square root was 0. 65. The 3D deviation was distributed mainly within 1 mm interval, with a distribution frequency of 96. 27％. Conclusions A 3D printed model prepared by high precision equipment is accurate enough to guide reconstruction of distal radius fractures in adults. In the treatment of complex fractures of the distal radius, a 3D printed model of the contralateral healthy distal radius can be used as a reference to achieve anatomical reduction and precise reconstruction of the fractured distal radius.
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Objective To understand family function ,social support ,preoperative anxiety and depression status among elder‐ly operative patients ,and to explore their relationship .Methods 295 elderly preoperative patients were investigated by family AP‐GAR index (APGAR) ,social support rating scale (SSRS) ,self‐rating anxiety scale (SAS) and self‐rating depression scale(SDS) , descriptive and inferential analysis .Results Among 295 elderly preoperative patients ,there were 208 people with good family func‐tion ,accounting for 70 .51% ,67 people with moderate disability family function ,accounting for 22 .71% ,and 20 people with severe disability family function ,accounting for 6 .78% ;The total score of social support was 40 .42 ± 9 .03 and the scores of subjective support was 23 .32 ± 5 .42 ,objective support with 9 .45 ± 3 .73 and support availability with 7 .65 ± 1 .86 ;152 people were preoper‐ative anxiety ,accounting for 51 .53% ,98 people were preoperative depression ,accounting for 33 .22% .The rate of anxiety and de‐pression good family function group was lower than a family dysfunction group(P<0 .05) .The incidence of depression high social support group is higher than low group (P<0 .05);Among the scores of social support ,subjective support ,objective support and support availability ,we find that patients with family well‐functioning group was higher than patients with family dysfunction group (P<0 .05) .Multiple logistic regression analysis showed that influence factors of preoperative psychological abnormality had educa‐tion level ,whether the tumor diseases ,the total score of social support and family functioning condition .Conclusion Elderly preop‐erative patients have anxiety and depression to a certain extent .The anxiety and depression of patients were related to the family function and social support .We Should pay attention to the effect of farmily function and social support on mental health of elderly patients with operation ,and effective use .
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Objective To investigate the protective effects of ulinastatin on express of GRP 78、CHOP and caspase-12, the molecules related to endoplasmic reticulum stress (ERS),after ischemia reperfusion injury in rats.Methods Ninety rats were equally randomized into 3 groups(n=30): Sham group (S group,n=30), Ischemia -reperfusion group (I/R group, n=30), Ulinastatin group (U group, n=30).Focal transient cerebral ischemia model was established with intralu-minal occlusion fo left meddle cerebral artery .Made through 2 hours of temporary middle cerebral artery occlusion , followed with 24 hours of reperfusion .The pathological results were investigated by HE staining and the cerebral injury situation was e -valuated by neurological deficit scores .Infract volume was measured by TTC staining , apoptosis was detected by TdT -medi-ated dUTP and nick end labeling (TUNEL), and expression of GRP78, CHOP and caspase -12 were meastured by western blot.Results Compared with the S group , the number of apoptotic cells were significantly increase in I /R group and U group (P<0.05);infarct volume and expression of GRP -78, CHOP and caspase-12 were significantly increased in I/R group and U group (P<0.05).The infarct volume and the number of apoptotic cells were significantly less in U group than in I/R group ( P<0.05 ) .GRP78 expression was higher in U group than in I/R group ( P<0.05 ) , however CHOP and caspase-12 expression was less in U group than in I/R group (P<0.05).Conclusion Ulinastatin has a protective effect on cerebral ischemia reperfusion injury , which may related to increased GRP 78, decreased CHOP and caspase -12 expres-sion and to inhibition of the ERS -induced apoptosis pathway .
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Objective To systemically evaluate the clinical therapeutic effect and safety of traditional Chinese medicine on Kawasaki disease. Methods Through retrieval of the reports in PubMed, the Cochrane Library, China National Knowledge Internet (CNKI), VIP database, Wanfang database by computer, the correlative articles of clinically randomized controlled trials (RCTs) published in China during the period from 1990 to 2013 were collected, and their quality evaluation was made. All the articles were screened according to inclusion and exclusion criteria, in which interventions were traditional Chinese medicine therapy and conventional western treatment. The articles selected were assessed with the software of RevMan 5.2. Results There were 212 articles searched out, but only 13 articles, 656 children with Kawasaki disease were conformed to the inclusion criteria. The Meta analysis indicated that the total effective rate in the traditional Chinese medicine group was superior to the group treated with western medicine. The difference in the curative effects between the two groups had notable significance [odds ratio (OR) = 3.58, 95%confidence interval (95%CI) was 2.16-5.93, test for overall effect Z=4.94, P<0.000 01]. No difference was seen in the curative effect of improving coronary artery changes between the traditional Chinese medicine group and western medicine control group (OR=2.03, 95%CI was 0.74-5.62, test for overall effect Z=1.37, P=0.17). Conclusion The clinical therapeutic effect of traditional Chinese medicine on Kawasaki disease is superior to that treated by western medicine.
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OBJECTIVE To explore the role of runt-related transcription factor 3(RUNX3) in the tumorgenesis and progression of cervical carcinoma. METHODS The immunohistochemical staining technique was used to detect the expression of RUNX3 protein in 25 cases of normal cervix, 34 intraepithelia neoplasia (CIN), and 48 cervical carcinomas. SYBR Green I chimeric fluorescence Real-time PCR was applied to detect the expression of RUNX3 mRNA in 10 cases of normal cervix, 24 CIN, and 30 cervical carcinomas. RESULTS The expressions of RUNX3 protein and mRNA in normal cervix, CINI,CINII-III, and cervical carcinoma tissues tended to be down-regulated. There was significant difference among these groups (P 0.05). CONCLUSION RUNX3 may function as a tumor suppressor gene in the occurrence and progression of cervical carcinoma.
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Adult , Female , Humans , Middle Aged , Carcinoma, Squamous Cell , Genetics , Metabolism , Uterine Cervical Dysplasia , Genetics , Metabolism , Core Binding Factor Alpha 3 Subunit , Genetics , Metabolism , Disease Progression , RNA, Messenger , Genetics , Metabolism , Uterine Cervical Neoplasms , Genetics , MetabolismABSTRACT
This study was aimed to determine the effects of respiratory phase, age, sex and body mass indexes (BMI) on the visibility and morphological characteristics of the diaphragmatic sternocostal triangle in normal adults shown by multi-detector computed tomography (MDCT). A total of 100 normal adults were consecutively recruited and scanned with 16-row MDCT at the end of deep expiration and inspiration. The visibility and morphological characteristics of diaphragmatic sternocostal triangle were observed. All cases were grouped according to the respiratory phase, age, sex and BMI, respectively. The visibility rates by MDCT among different types of sternocostal triangles at the inspiratory or the expiratory phases were calculated and compared, and the visibility rate was correlated with age, sex, and BMI, respectively. In addition, the CT features of diaphragmatic hernia (n=2) were recorded and analyzed. The visibility rate of trigonum sternocostal was 43% at the end of inspiration and 32% at the end of expiration. No difference was found in regard to age, gender and BMI (P > 0.05). Rupture of diaphragm and the features of adjacent abdominal organs into thoracic cavity were revealed clearly on multiplanar reformation (MPR) images of MDCT in 2 patients with diaphragmatic hernia. The visibility rates of diaphragmatic sternocostal triangle were associated with the respiratory movement. MPR on MDCT could be useful for revealing the anatomic structure of diaphragm and the radiological features of diaphragmatic hernia. Furthermore, double-phase scanning of MDCT provides feasible method for studying the physiologic information of diaphragm movement in normal status and abnormal status.
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Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Young Adult , Diaphragm , Diagnostic Imaging , Hernia, Diaphragmatic , Diagnostic Imaging , Imaging, Three-Dimensional , Respiration , Sternocostal Joints , Diagnostic Imaging , Tomography, Spiral Computed , MethodsABSTRACT
Objective To explore the role of hypothermia in curing patients with acute cerebral infarction. Methods 40 patients with final diagnosis of acute cerebral infarction in our department from 2007-3 ～ 2009-1 were selected and randomly divided into hypothermia group and normathermia group. Both groups were treated with the same approach except the hypothermal intervention in hypothermia group. Prognosis,infarct size and the rate of revas-cularization were compared between the groups after 1 month following up. Results When compared with the normathermia group,the hypothermia group had better prognosis and less infarct size after treating,but statistical significance could not find in two groups in the rate of revascularization. Conclusion Under a series of mechanism,hypothermia could grow down the local infarct size and make important sense to improve the prognosis of patients with acute cerebral infarction.
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Objective To explore the role of transcranial doppler(TCD) on therapeutic effects of intravenous thrombolysis for patients with acute cerebral infarction by using transcranial doppler to make dynamic detection pre and pro-intravenous thrombolysis. Methods 60 patients with the final diagnosis of acute cerebral infarction were selected according to the inclusion criteria and exclusion criteria standard promissory. Recombinant tissue type plasminogen activator as the intravenous thrombolysis agent was used 4.5h later onset of the disease in all these cases, and TCD monitoring was preformed to understand the sitiations of the target blood vessels pre and pro-thrombloysis treatment on the 6,12 hours and 24 hours,the 2st day and the 7th day,all the data offered by which was used to adjust the treatment protocois of antiplatelet and anticoagulant therapy after 24 hours. All patients were followed up for 3 months,among whom prognostic evaluation, situations of revascularization was carried out as well as the complications of secondary intracranial hemorrhages and reocclusion basing on the neurologic impairment Score and the Thrombolysis in Brain lschemia(TIBI) respectively. Results No patient was dead after following-up for 3 months and 17 cases with basi- healing(28.3%) ,20 cases with excellence(33.3%), 16 cases got better(26.7%) ,3 cases with inefficiency (5.0%), and 4 cases became deterioration (6.7%). According to the Thrombolysis in Brain lschemia( TIBI), 22 cases got 4-5 level( 36.7 %), 31 cases with 2-3 level ( 51.7% ), and 7 cases got 0-1 level ( 11.6 % ). Among all these cases ,4 cases were found with secondary intracranial hemorrhages (6. 7% ) and 5 cases with reocclusion ( 8.3% ) Conclusion Dynamic detection with transcranial doppler pre and pro-intravenous thrombolysis could improve the therapeutic effect on patients with acute cerebral infarction, and reduce its complication, which is important for the clinical wrok and deserving consulting.
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Objective To explore the influence of diastolic blood pressure to prognosis of patients with acute cerebral infarction. Methods Clinical data of 200 patients with acute cerebral infarction were retrospectively reviewed Patients were divided into three groups based on diastolic blood pressure(DBP)when admission;hypotensive group(DBP＜70 mm Hg),normotensive group(DBP;70-90 mm Hg)and hypertensive group(DBP ＞ 90 mm Hg).Constituent ratio of patients with different level of DBP were calculated and prognosis were compared among the three groups. Results Of all the total patients with acute cerebral infarction,8%(16)presented with hypotension,12%(24)were normotensive and 80%(160)were hypertensive.In the hypotensive group,50%(8)patients died as compared to 17%(4)in normotensive group and 38%(60)in hypertensive group,among all the cases,patients with bypotension or hypertension seemed like to have a higher mortality than normotensive group(P=0.037;x2=3.993,P=0.046),and there was no significant diffenence between two group with hypotension or hypertension. Conclusion The patients with diastolic blood pressure of less than 70 mm Hg or more than 90 mm Hg were predictors of poor outcome.
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The aim of this study was to elucidate the characteristics of time attenuation curve and CT perfusion parameters for pulmonary adenocarcinomas and squamous cell carcinomas. 58 cases of pulmonary adenocarcinomas and 27 cases of squamous cell carcinomas underwent first pass CT perfusion imaging with 64-row MDCT. Data were analyzed using commercial software to generate time attenuation curve (TAC) and CT perfusion parameters, including perfusion, peak enhanced (PE), time to peak (TTP), and blood volume (BV). For TAC, there were 36.2% of type I and 63.8% of type II in adenocarcinomas, while there were 22.2% of type I and 77.8% of type II in squamous cell carcinomas. There was not significant difference (P>0.05). Perfusion, PE, TTP and BV of adenocarcinomas were 63.2 +/- 45.4 ml x min(-1) x ml(-1), 60.2 +/- 46.6 Hu, 34.8 +/- 10.2 s and 34.3 +/- 23.6 ml x 100 g(-1), respectively, while 54.3 +/- 50.2 ml x min(-1) x ml(-1), 48.5 +/- 34.9 Hu, 36.1 +/- 11.2 s and 27.6 +/- 21.7 ml x 100 g(-1), for squamous cell carcinoma, respectively. No significant differences were found between groups (P>0.05). No significant differences in TAC and CT perfusion parameters were found between adenocarcinomas and squamous cell carcinomas.
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Adult , Aged , Female , Humans , Male , Middle Aged , Adenocarcinoma , Diagnostic Imaging , Carcinoma, Squamous Cell , Diagnostic Imaging , Image Interpretation, Computer-Assisted , Methods , Lung Neoplasms , Diagnostic Imaging , Neovascularization, Pathologic , Diagnostic Imaging , Pathology , Perfusion , Methods , Prospective Studies , Tomography, Spiral Computed , MethodsABSTRACT
The objective of this comparative study is to determine the MDCT features of solitary pulmonary tuberculous cavity and malignant cavity and to analyze the advantages there-of in differential diagnosis. The clinical data and MDCT findings of 51 cases of pulmonary tuberculous cavities and 39 cases of malignant cavities were reviewed retrospectively, which include the general aspects of patients, the manifestation of cavity and the changes of adjacent structures. The results revealed that the tuberculous cavity tends to locate in the upper lobe or the superior segment of lower lobe, and it is usually acompanied with cavity wall calcification, satellite lesions, peripheral inflammation, lymph node calcification, small diameter and thin wall thickness. The malignant cavities, showing no disposition to locate in a lobe or segment, are characterized by mural nodules, off-center cavity, lobulation, coarse speculation, lymph node enlargement, vascular clustering sign, big diameter and thick wall. In conclusion, with multiplanar reconstruction on multi-detector row CT, we could elaborate the cavities and the accompained lesions, thus contributing to a correct diagnosis in most cases.
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Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Young Adult , Adenocarcinoma , Diagnostic Imaging , Pathology , Carcinoma, Squamous Cell , Diagnostic Imaging , Pathology , Diagnosis, Differential , Lung Neoplasms , Diagnostic Imaging , Pathology , Retrospective Studies , Tomography, Spiral Computed , Methods , Tuberculosis, Pulmonary , Diagnostic Imaging , PathologyABSTRACT
To elucidate the MR urography (MRU) features of ectopic ureter orifice in children and to explicate its advantages, the clinical data and MRU findings of 4 cases with ectopic ureter orifice were analyzed retrospectively. Among the 4 cases of ectopic ureter orifice, 2 were associated with dysplasia of kidneys, 1 was associated with duplex kidney, and the remaining 1 was associated with cross ectopic and dyplasia kidney. When combining the MRI and MRU examination, we could diagnose the ectopic orifice of the draining ureters. So we concluded that definitive diagnosis could be achieved in most of the cases by integrating clinical information with MRU findings.
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Child , Child, Preschool , Female , Humans , Male , Abnormalities, Multiple , Diagnosis , Kidney , Congenital Abnormalities , Magnetic Resonance Imaging , Retrospective Studies , Ureter , Congenital Abnormalities , Ureteral Diseases , DiagnosisABSTRACT
AIM: The differentiation theory on kidney turbidity is used to recognize the relevant characters of Alzheimer disease. METHODS: The analysis is carried on the interrelationship between kidney turbidity and Alzheimer disease in the aspects of pathology, pathogenesis and clinical manifestations. RESULTS: It was discovered in modern neural pathological examination that in the patients with Alzheimer disease, the cerebral cortex was atrophic, the convolution becomes flat, the cerebral groove was widened, the ventricle was extended, brain weight was declined and cortical nerve cells were de creased in various degrees. All of those changes were the manifestations of kidney essence deficiency in Chinese medicine. The main mechanism on neuron loss caused by Alzheimer disease was that oxygenic free radical works on nerve neurons and induces the increased Ca2+ inner-flow. Con cerning to the theory of Chinese medicine, oxygenic free radical was taken as "kidney turbidity". In the patients with Alzheimer disease, insufficient kid ney essence resulted in malnourishment of heart. In addition, upward dis turbance of kidney turbidity and abnormality of heart mind projected the brain and affected brain function, resulting in recent memory disturbance that was the initial symptom of Alzheimer disease. CONCLUSION: Concerning to the treatment of Alzheimer disease, Chinese medicine emphasizes not only on reinforcing kidney and filling-up essence, but also rather on eliminating kidney turbidity, for which, the method of re solving turbidity and damp is applied specially.
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@#ObjectiveTo study the method and effect of individualized education on children with learning disability (LD).Methods30 children during 7-10 year old in a local boarding elementary school were chosen and guided individually as the following: sensory integration dysfunction drill, subtle motion drill, life skills drill, cognitive capability drill, behavior therapy, game therapy, music therapy and parents education. One and a half year later, the index of Sensory Integration Rating Scales and study marks were determined and compared with that of the normal children.ResultsThere is not significant difference between the LD children and the normal ones in the sensory integration of behavior and the learning achievement.ConclusionIndividualized education is a valid approach improving the potentiality of the LD children\'s physiology and psychology.