ABSTRACT
Objective:To systematically evaluate the clinical efficacy and safety of Xixian Tongshuan Capsules/Pills combined with Western medicine in treating cerebral infarction.Methods:All RCTs about Xixian Tongshuan Capsules/Pills combined with Western medicine in treating cerebral infarction were retrieved from CNKI, Wanfang Database, VIP database, PubMed and CBM. The search period was from the database establishment to December 31, 2021. Two researchers independently extracted the basic literature data and evaluated the methodological quality, then used RevMan5.4 software for meta-analysis.Results:Totally 9 articles were included, involving a total of 988 patients, including 505 cases in the observation group and 483 cases in the control group. Meta-analysis showed that the total effective rate of Xixian Tongshuan Capsules/Pills combined with Western medicine in treating cerebral infarction was higher than that of conventional Western medicine [ RR=1.20, 95% CI (1.13, 1.27), P<0.05]. At the same time, the effect of NIHSS score, Barthel score and FIB were better than those of conventional Western medicine [respectively: MD=-3.21, 95% CI (-4.45, -1.97), P<0.05; MD=11.83, 95% CI (10.66, 13.00), P<0.05; MD=-0.95, 95% CI (-1.36, -0.54), P<0.05]. After treatment with Xixian Tongshuan Capsules/Pills combined with Western medicine, the adverse reactions mainly included dizziness, nausea, indigestion, rash, facial blushing, etc. There was no statistically significant difference in safety between the two groups [ RR=1.50, 95% CI (0.75, 3.01), P>0.05]. Conclusions:Under the treatment of conventional Western medicine, the addition of Xixian Tongshuan Capsules/Pills can improve the clinical efficacy of cerebral infarction treatment, effectively improve the symptoms of neurological impairment, improve the ability of daily life, and promote the prognosis and recovery, and without increasing the incidence of adverse reactions. However, large sample and high quality studies are still needed to support the conclusion.
ABSTRACT
In recent years, the research on gold nanoparticles has made great progress. Gold nanoparticles with different morphologies have good application prospects in drug delivery and tumor treatment. Some gold nanoparticles have entered the stage of clinical trials. Gold nanorods have become important research objects due to their special optical properties and photothermal treatment potential. In this paper, the optical properties and main applications of gold nanorods were reviewed. Gold nanorods have good surface modifiable properties and can be modified through surface ligand exchange to improve their biocompatibility. The photothermal properties of gold nanorods can be improved by adjusting the aspect ratio to adjust the surface plasmon resonance (SPR) peak to achieve near-infrared light excitation. These characteristics make gold nanorods show good application prospects in the detection of biological macromolecules, real-time imaging in vivo, and early diagnosis and treatment of tumors. Using gold nanorods as a carrier and modified with different targeting molecules can improve the targeting of its drug delivery system and reduce damage to normal cells, so as to realize the combined application of chemotherapy and photothermal therapy, and finally achieve a better therapeutic effect. Combining gold nanorods with stem cells or certain specific biomolecules can form a hybrid gold nanorod system which provides new ideas for further improving the efficiency of tumor treatment.