ABSTRACT
Objective To explore the relationship between N-acetyltransferase-2(NAT2)alleles polymorphism and type 2 diabetes mellitus(T2DM).Methods Polymerase chain reaction and sequence determination technique were used to identify NAT2 alleles in 174 patients with T2DM(T2DM group)and 174 unrelated healthy individuals(control group).Results Compared with control group,the allelic frequency of NAT2 mutation was no significant difference in T21DM group(x2=7.38,P＞0.05).The frequencies of the NAT2 genotypes(Wt/Wt,Wt/M1,Wt/M2,Wt/M3,M1/M1,M1/M2,M1/M3,M2/M2,M2/M3,M3/M3)were 39.08％(68/174),3.45％(6/174),22.99％(40/174),14.94％(26/174),0.57％(1/174),2.30％(4/174),1.15％(2/174),4.60％(8/174),9.20％(16/174),1.72％(3/174)and 44.83％(78/174),2.60％(8/174),27.59％(48/174),17.24％(30/174),0.57％(1/174),0.57％(1/174),0.57％(1/174),1.15％(21174),2.30％(4/174),0.57％(1/174)respectively,and significant differences showed between T2DM group and control group(x2=13.92,P＜0.01).The proportion of fast acetylate in T2DM group was significantly higher than that in control group[94.25％(164/174)vs.80.46％(140/174)],and the propoaion of slow acetylate in T2DM group was significantly lower than that in control group[5.75％(10/174)vs.19.54％(34/174)](P＜0.05),The risk of T2DM in people who were fast acetylate had 3.98 times(95％ CI:1.90-8.35)more than that in people who were slow acetylate.Conclusion It shows that the fast acetylate may be one of the genetic factors that influencing the susceptibility to T2DM,and slow acetylate may be one of the protecting factors.