Evaluation of changes of kidney parmeter in New Zealand rabbits subseqent to 90 days exposure to uranyl nitrate in drinking water

This study was undertaken to examine the reversibility of renal injury in the male New Zealand white rabbits subsequent to a 90-days exposure to uranyl nitrate [UN] in drinking water. Animals were exposed for 90 days to uranyl nitrate in their drinking water [24 or 500mg/l]. Control group were given municipal tap water. The indicators of kidney function measured in this study included glucose [marker of tubular] microalbumin[marker of glomerular] and marker for cell toxicity was alkaline phosphatase. Urinary glucose was found to be significantly different and positively correlated with uranium intake for rabbits. Microalbuminuria was found to be significantly different but this different is in normal range. Increase of alkaline phosphatase at weeks 2, 4, 6 was correlated with uranium intake, but at weeks 8, 10, 13 excretion of alkaline phosphatase was decreased. These results suggest that chronic ingestion of uranium in drinking water affect kidney function and to the proximal tubule, rather than glomerul

[Evaluation of kidney function in Male New zealand white rabbits, subsequent to a 90 days exposure to uranyl nitrate in the drinking water]

This study was undertaken to examine the reversibility of renal injury in the male New Zealand white rabbits, subsequent to a 90-days exposure to uranyl nitrate [UN] in the drinking water. Animals were exposed for 90 days to uranyl nitrate in their drinking water [24 or 500mg/l] The control group were given municipal tap water. The biomarkers of kidney function measured in this study included beta-2 micro globulin [marker of tubular], micro albumin [marker of glomerular] and the marker for cell toxicity was catalase. Excretion of beta-2 micro globulin was to be significantly different and was correlated with uranium intake for rabbits in early weeks. Microalbuminuria was found to be significantly different but this different was within normal range. Catalasuria was not significantly different in this study. These results suggest that chronic ingestion of uranium in the drinking water affects kidney function and is related to the proximal tubule, rather than glomerul