ABSTRACT
Kidney transplantation is associated with various biochemical abnormalities such as changes in serum blood level of sodium [Na], potassium [K], calcium [Ca], and phosphorous [P]. Although cy-closporine [CsA] is used commonly the prevalence of its side effects, including electrolytes disturbance, is not well understood. To find the prevalence of electrolytes disturbance and its relation to CsA blood levels. In a retrospective study 3308 kidney transplant recipients transplanted between 2008 and 2011 were studied. We evaluated the relation between serum Ca, P, Na, K and CsA trough [C[0]] and 2-hour post-dose [C[2]] levels. The meantSD age of recipients was 37 +/- 15 years; 63% of patients were male. Overall, C2 levels had correlation with Ca blood level [p=0.018; OR: 1.13, 95%CI: 1.02-1.25], CQ levels had also correlation with blood levels of P and Cr [p<0.001; OR: 1.83, 95% CI: 1.59-2.11]. Electrolyte disturbances are prevalent. Higher serum levels of CsA can worsen the allograft function by disturbing the serum P and Ca levels
ABSTRACT
With the success of kidney transplantation, liver disease has emerged as an important cause of morbidity and mortality in kidney recipients. To determine the impact of hepatitis B virus [HBV] infection on patients and graft survival in both short- and long-terms. 99 renal transplant patients infected with HBV on follow-up in two major transplant centers were included in a retrospective study. These patients were grafted between 1986 and 2005 and divided into two groups: [1] those only positive for hepatitis B surface antigen [HBsAg] and [2] those who were also positive for hepatitis C virus antibodies [HCV Ab]. There were 88 patients with HBsAg[+] and 11 with both HBsAg[+] and HCV Ab[+]. The mean +/- SD age of patients was 38.8 +/- 13.2 years, and the median follow-up after transplantation was 19 months. Although not significant, the allograft survival rate in the first group [HBV[+] was better compared to that in the second group [HBV[+] and HCV[+]; 1, 5 and 10 years graft survival rates were 91, 77 and 62 in the first group and 70, 56 and 28 in the second group, respectively [P=0.07]. The overall mortality was 5% [4 of 88] in the first and 27% [3 of 11] in the second group [P=0.02]. Renal allograft recipients with HBV and HCV infections has a poor survival rate compared to pa- tients with only HBV infection. However, there is no significant difference in terms of renal graft survival between the two groups