[Comparison of Atorvastatin with placebo in the treatment of paederus dermatitis]

Paederus dermatitis is a blistering disorder of skin caused by a small insect called paederus transmitted by displaced beetles of order Coleoptera. There are limited studies on classical treatment of this disease. The aim of this study was to compare therapeutic effects of atorvastatin with placebo in the treatment of paederus dermatitis. This was a randomized double-blind clinical trial and was carried out in the hospital and clinics of Sari and Neka cities for 6 months. Experimental group [15 patients] received atorvasatin and control group [15 patients] received placebo. All the patients were examined at the first, seventh and fourteenth days after treatment. Data were recorded in a questionnaire for every patient. Complete recovery and failure of treatment were compared in both groups. Data were introduced into SPSS software and analyzed by means of X2 test. A total of 15 patients were treated, 10 patients from Sari and 5 from Neka cities. Most of the patients were between 26-45 years of age. Most of patients were married; all of them educated, and were civil servants or had private jobs. Full recovery rate of the patients was 93.33% in the second visit [seventh day]. The rest of the patients recovered in the third visit [fourteenth day]. 30.43% of the patients had lesions on the neck, and size of the lesions was between 6-10 cm2 in 42.85% of cases. There was a significant difference in recovery rate between experimental and placebo groups [P<0.05]. In this study, all patients were recovered completely within 14 days, whereas only 13.3 percent were recovered in control group

[Comparison of therapeutic and anti-inflammatory effects of topical triamcinolon with placebo in the treatment of paederus dermatitis in guinea pig]

Dermatitis caused by paederous insect is considered a public health problem in many parts of the northern, and some of the southern areas of Iran. The aim of this study was to evaluate the effect of topical triamcinolone on the treatment of linear dermatitis in animal model. 20 male guinea pigs [Cavia porcellus] were divided into treatment and control groups [N=10]. Animals had free access to food and water and were kept at 25§C and 50% humidity. Paederus beetles caught from the city of Neka, transferred to the School of Public Health in Tehran. Guinea pigs developed linear dermatitis on contact with peaderus beetles. Triamcinolone ointment [0.1%] was applied on the skin of the pigs for 14 days after shaving their hair. The recovery rate was assessed on the first, third, fifth, seventh, ninth, eleventh and fourteenth days after drug administration in the treatment and control groups. The control group used placebo without alcohol base. The mean weight of the guinea pigs was 700 +/- 10 gr. At the end of the ninth day all the guinea pigs in the treatment group improved while 10% of the guinea pigs in the control group showed improvement [P>0.05]. There were no serious medical complications during and one month after the treatment course. This study showed that triamcinolone had significant beneficial effects on the treatment of linear paederus dermatitis in animal models and it can be considered as an effective drug for the treatment of this dermatitis in human models in the future studies