ABSTRACT
Lignin urethanes [carbamates] were prepared from dioxane lignin which was separated from saw dust of hard wood, supplied from a local workshop. Dioxane lignin is allowed to react with phenyl and ethyl isocyanate to form different lignin urethanes. The toxicological studies of the two derivatives were prepared to find out the interrelationship between the chemical structure and the toxicity induced by them. Determination of the LD30 showed that the phenyl lignin urethane is more toxic than the ethyl lignin urethane. The severity of toxic symptoms was found to be affected by the changes in the side chain. This has thrown some light on the way which we practically use for poisoning rats. The most active compound possesses higher molecular weight and a number of nitrogen atoms in the molecular formula. IR spectra revealed that the most active compound, phenyl lignin urethane has 1:2:4 aromatic beside 1:2: and 1:4 aromatic substitutions. Electronic spectra demonstrated that phenyl and ethyl lignin urethanes possess a shoulder peak at 280 mu than dioxane lignin [parent Cpd] due to more conjugated chromophores. Further studies are needed to support our conclusion