Radioprotective role of vitamin E and testosterone against radiation effects on serum cholesterol and free fatty acids of irradiated rats

The present study has been carried out to evaluate the radioprotective efficiency of vitamin E and testosterone for protecting the levels of serum total cholesterol and free fatty acids from deleterious radiation effects. Whole body gamma irradiation of rats at the dose of 7 Gy induced significant increase in the level of serum total cholesterol. This increase was 35.9, 103.3, 46.3, 47.3 and 40.0% on the 1st, 3rd, 7th, 10th and 14th days post irradiation respectively, as compared to normal control values. As for free fatty acids content, a significant decrease was observed at the 3rd and 14th days post irradiation, while insignificant changes were recorded on the 1st, 7th and 10th days after irradiation. The treatment of rats with intraperitoneal injection of either vitamin E or testosterone pre-whole body gamma irradiation reduced the changes induced in the levels of studied parameters. The observed recovery was more clearly pronounced in the rats treated with vitamin E than in treated rats with testosterone

Prophylactic action of testosterone on lipid metabolism of liver and serum in gamma irradiated albino rats

The present study has been carried out to investigate the efficiency of testosterone as a radioprotector agent. The levels of total lipids and triglycerides as well as the lipolytic activity of liver and serum in gamma irradiated rats were selected for this study at periods of 1, 3, 7, 10 and 14 days post irradiation.The results indicated that whole body gamma irradiation at the dose of 7 Gy caused different significant changes in the levels of total lipids and triglycerides of the liver. However an evident elevation in serum total lipids and triglyceride contents produced at all post irradiation days. The enzymatic activity of serum and liver lipase significantly increased on the 3rd and 7th days post-irradiation and decreased at the other experimental times. Pre-treatment of rats with testosterone, 10 days, before whole body gamma irradiation [7 Gy] has minimized the variation occurred in the levels of the studied parameters in both liver and serum