ABSTRACT
The study was done to gain experience with the active immunization method for vaccine potency testing. It also determined the relative potency of locally prepared vaccines compared with foreign prepared vaccinesWhite Swiss mice equally distributed as to sex were used as control and test groups. Granular mucin type 1201-w, strain of Salmonella typhosa, and three vaccines (vaccines A,B, and C) were used. The procedure used was the mucin technique of RakeThe LD50 dose was found to be 0.5 ml of a dilution of 10-5-752. It was felt necessary to enhance virulence of the organism, thus another determination was done after two passages. Results of potency determination showed that vaccine A gave a protection to approximately 1,500 LD50 dose. However, vaccines B and C failed to protect immunized animals against the minimal number of LD50 doses measurable in the range of the tests conductedFurther studies involving V: antigen are deemed needed to supplement this initial experience
ABSTRACT
1. Complement levels were studied in 41 normal adults and 40 cancer cases2. Complement levels measured by the two mehtods, CIA50 and CH50 units, showed statistically higher levels among cancer cases as compared with normal adults. Mean titers were 31o7 CIA50 units per 0.5 ml. and 35.7 CH50 units per ml. for normal adults and 4385 CIA50 units per 0.5 ml. and 51.8 CH50 units per ml. for cancer cases3. There was a tendency towards correlation in the two measurements so that a high level of CIA50 units was accompanied by a similar increase in CH50 units4. The significnce of the high complement levels among cancer cases and its relationship to resistance is discussed. (Conclusions)