Progress in evidence-based research on the clinical treatment of infantile hemangioma and vascular malformations / 口腔疾病防治

@#Hemangiomas and vascular malformations are common clinical diseases. According to their clinical and imaging characterizations, the International Society for the Study of Vascular Anomalies (ISSVA) has systematically classified infantile hemangioma and vascular malformations, and the classification has been widely recognized and applied. To date, most vascular malformations involve the following important signaling pathways: PI3K/Akt/mTOR and RAS/MAPK/ERK. This discovery has major impacts on the diagnosis and treatment of vascular malformations including the following: the understanding of the biology of vascular malformations has been increased; the understanding of vascular malformations based on genotype has been refined; and the development of targeted drugs for the treatment of vascular malformations has been promoted. Despite facing many challenges, with the development of gene sequencing, molecular biology and imaging technology, the relevance of vascular malformation classification and the accuracy of diagnosis are improving, and this is accompanied by innovations in surgical treatment and sclerotherapy, interventional embolization, and continuous progress in targeted therapy. At present, investigations on vascular malformations are mostly retrospective clinical studies or low-level clinical trials. The purpose of this paper is to review the literature on the treatment of infantile hemangioma, lymphatic malformation, venous malformation and arteriovenous malformation and to review the research progress in evidence-based treatment of infantile hemangioma and vascular malformation.

Influence of public physical education course integrating physical fitness training on college students’ physical health / 中国学校卫生

Objective@#To explore the influence of public physical education curriculum integrated with physical fitness training on college students’ physical health,and to provide a reference for improving physical health of college students.@*Methods@#A total of 280 freshmen from 6 classes in Qiqihar Medical University were selected, and all the participants were divided into two groups (3 classes in each group). The control group (n=132) received regular public physical education curriculum. The experimental group (n=148) received physical fitness training in addition on the public physical education curriculum. The experiment lasted for one semester. Physical fitness of the two groups of college students were tested, and the changes of physical health of the two groups before and after the experiment were compared.@*Results@#The qualified rate of physical health assessment before the experiment was close to that of the two groups (χ2=0.24，P>0.05). Compared with that before the experiment, the qualified rate of physical health assessment after the experiment in the experimental group was significantly higher than that in the control group (χ2=22.52，12.39，P<0.05). The scores of physical health assessment of boys and girls in the experimental group after the experiment were significantly higher than those before the experiment (boys:t=6.87,7.99,8.05,5.02,6.94,10.05; girls:t=5.88,6.32,7.08,9.84,6.17,4.06,P<0.05). The test results of vital capacity, 50-meter running, sitting forward bending, standing long jump, pull-up and 1 000-meter running in the experimental group were significantly better than those in the control group(t=7.26,4.30,8.07,2.34,8.31,4.20,P<0.05). After the experiment, the test scores of vital capacities, 50-metre running, sitting forward bending, standing long jump, sit-up and 800-metre running in the experimental group were significantly better than those in the control group (t=8.64,5.81,5.53,22.27,9.60,13.06,P<0.05).@*Conclusion@#Integrating physical fitness training in college public physical education curriculum can help improve the physique health level of college students, actively reform public physical education curriculum in colleges and universities, and explore the curriculum model suitable for the actual situation of each school is an important way to improve the physique health level of college students.

Progress in the genetics research of infantile hemangioma and vascular malformations / 口腔疾病防治

@#The etiology and pathogenesis of hemangiomas and vascular malformations are still unclear and face many challenges in terms of treatment. This article focuses on the etiology and genetic mechanism of common vascular tumors (such as infantile hemangiomas, congenital hemangioma and pyogenic granuloma) and vascular abnormalities (such as sporadic venous malformations, blue rubber bleb nevus syndrome, hereditary cutaneomucosal venous malformations, glomuvenous malformations, verrucous venous malformations, lymphatic malformations, and arteriovenous malformations). Some gene mutations have been identified and established. Several mutations in key proteins in the signaling pathways of endothelial cells (ECs) have been shown to play a major role in the pathogenesis of vascular abnormalities. Mutations in PIK3CA and G-protein coupled receptors were most frequently identified. The detection of genetic or somatic gene mutations is important for elucidating the underlying molecular mechanisms and developing effective therapeutic approaches.