ABSTRACT
1. Seventy-two Strong A mice (male) were pre-treated with formalin-killed EAT cells injected to the subcutis at the inter scapular area once a week for three consecutive weeks. These were challenged later with live EAT cells on the fourth week and observed for tumor growth. There was marked diminution of the tumor weights in the experimental group in comparison with those in the controls. In 29.8 percent of the experimental mice, total inhibition of EAT growth was observed2. Further studies will be done in an effort to elucidate this phenomenon. (Summary)
ABSTRACT
1. The results of this investigation would indicate that the total alkaloids of Alstonia macrophylla possesses a moderate hypotensive activity which is similar to that produced by the alkaloids of Rauwolfia, although other activities are not the same2. These hypotensive activities observed in the experimental animals show a possibility of a potent drug to lower the blood pressure of individuals with pertension3. The cardiovascular effects as shown in the electrocardiographs do not seem to be the main effect or activity of the drug on oral administration although it caused reversal of certain ECG tracings back to normal4. Further studies currently under way are designed to find out the mechanism of the hypotensive activity. The potentialities of the alkaloids may pave a way for a new anti-hypertensive from a local plant. (Comments)