ABSTRACT
Objective: To evaluate the effect of preoperative intravitreal bevacizumab injection on the incidence of postoperative haemorrhage and visual prognosis, in patients undergoing 25-gauge micro incision vitrectomy surgery [MIVS] for diabetic vitreous haemorrhage
Methods:One hundred and twenty two eyes of 122 patients of diabetic retinopathy of both genders and aged over 18 years, who presented with non-resolving vitreous haemorrhage were enrolled for this study. All patients received an intravitreal injection of 1.25 mg/0.05 mL bevacizumab [Avastin] which was followed one week later by 25-gauge sutureless micro incision vitrectomy surgery. Main outcomes measured were best corrected visual acuity [BCVA] assessed with logMAR and post-operative vitreous haemorrhage. Follow ups were up to six months post-operatively. IBM SPSS 21 was used for data analysis
Result: A total of 122 patients were included; 78 [63.9%] males and 44 [36.1%] females. Mean age at the time of surgery was 51.4 +/- 13.66 years. The mean preoperative BCVA was 1.64 +/- 0.427 logMAR which improved to 0.57 +/- 0.253 logMAR at 12 months post-operatively [p-value < 0.001]. Recurrent vitreous haemorrhage was seen in four patients [3.28%]. one1 week before 25-gauge vitrectomy helps to reduce the incidence of early post-vitrectomy haemorrhage in diabetic patients