Measuring the amount of nickel and iron oxide in the breathing zone of welders

Diagnosis and measurement of air pollution in workplace is one of the most important aspects of controlling chemical agent and purpose of this study is to measure inhalation exposure welding fumes. In this study, with the help of a personal pump and ester cellulose filters, welding fumes in total working hours was measured. The samples prepared and analyzed by atomic absorption. The findings suggest that the inhalation of iron oxide is higher than threshold limit value but the amount of nickel is less than the limits. Results confirms the need for some corrective actions

CYBB gene mutation detection in an Iranian patient with chronic granulomatous disease

In this study, we report a mutation in CYBB gene in a patient with X-CGD [diagnosed on the base of family history, NDT test, DHR 123 assay]. Mutation in CYBB gene was detected using SSCP analysis [single-strand conformation polymorphism] followed by sequencing. During screening for mutations in the CYBB gene we observed 880 C T in exon 8. This mutation resulted in 290 Arg Stop. We also observed a change [-270 C A] in the promoter region which needs further investigation. We would like to pursue this study by analyzing more X-CGD patients to find out the CYBB mutation spectrum in Iranian patients