ABSTRACT
Tumor angiogenesis is essential for tumor growth and appears to play an importating role both in invasive growth and metastasis. Basal cell carcinomas [BCCs] and squamous cell carcinomas [SCCs] of the skin are derived from a similar cell type but differ in the invasive and metastatic potential. Basal cell carcinoma generally shows a relatively benign course in contrast to squamous cell carcinoma .This study investigates whether the behavior of these tumors could be explained by differences in their angiogenesis pattern. Vessel counts were made of blood vessels in stroma and the body of 50 variants of BCC of skin samples including: nodular, micronodular, sclerosing and superficial, both after H and E and immunohistochemical staining for CD31 and CD34 markers. The body vessel counts of invasive variants [sclerosing and micronodular] differed significantly from the counts of noninvasive variants [nodular and superficial] using both CD31 and CD34 markers. The stromal vessel counts compared between invasive and noninvasive variants showed no significantly difference using CD31 and CD34 markers, respectively. The invasive growth pattern of BCC variants correlated with the microvascular density and according to results, vessel counts of the body play a more important role
Subject(s)
Carcinoma, Basal Cell , Skin Neoplasms , Platelet Endothelial Cell Adhesion Molecule-1 , Antigens, CD34 , Neoplasm InvasivenessABSTRACT
Circumscribed juvenile pityriasisrubrapilaris[PRP] is a form of PRP that manifests with well-defined erythematous scaly plaques with follicular keratosis mainly over knees and elbows. There are several reports of the association of PRP with other conditions. We report a boy with scattered erythematosquamous skin lesions and follicular hyperkeratotic papules since the age of six years. Skin biopsy was compatible with PRP. He also had hypoparathyroidism and brachyonychia. To our knowledge, this association has not been reported so far
ABSTRACT
Patients with keratotic lesions distributed in a unilateral, linear, zosteriform or localized pattern and revealing histopathologic features of dyskeratoticacantholysis have been reported previously. There is some controversy in the appropriate nosologic classification of this entity. Some authors consider it as a localized form of Darier's disease while others place it as a variant of epidermal nevus. We report a 19-year-old girl who presented with 14 years history of an asymptomatic, hyperkeratotic area of skin-colored papules in a dermatomal distribution on the dorsum of her left hand and forearm. Pathological evaluation showed acantholysis and dyskeratosis. The controversy regarding the correct classification of such a patient is discussed