ABSTRACT
OBJECTIVE@#To evaluate the effects of Zhumeria majdae essential oil (ZMEO) on morphine dependence and tolerance in mice.@*METHODS@#ZMEO (10, 20, and 40 mg/kg) and clonidine (0.1 mg/kg) as the positive control were injected intraperitoneally (i.p.). The effect of ZMEO and clonidine on the dependence were evaluated by counting the number of jumps induced by naloxone (5 mg/kg) while the tolerance was evaluated by the tail-flick test.@*RESULTS@#ZMEO at the dose of 10 mg/kg during the development period led to a significant inhibition of morphine tolerance (P0.01), and significantly reduced the withdrawal signs (number of jumps) of mice (P>0.01).@*CONCLUSIONS@#ZMEO had significant effects on morphine tolerance and dependence. The linalool rich essential oil of Z. majdae plays a major role in the reduction of tolerance and dependence induced by morphine.
ABSTRACT
OBJECTIVE@#To evaluate the effects of Zhumeria majdae essential oil (ZMEO) on morphine dependence and tolerance in mice.@*METHODS@#ZMEO (10, 20, and 40 mg/kg) and clonidine (0.1 mg/kg) as the positive control were injected intraperitoneally (i.p.). The effect of ZMEO and clonidine on the dependence were evaluated by counting the number of jumps induced by naloxone (5 mg/kg) while the tolerance was evaluated by the tail-flick test.@*RESULTS@#ZMEO at the dose of 10 mg/kg during the development period led to a significant inhibition of morphine tolerance (P0.01), and significantly reduced the withdrawal signs (number of jumps) of mice (P>0.01).@*CONCLUSIONS@#ZMEO had significant effects on morphine tolerance and dependence. The linalool rich essential oil of Z. majdae plays a major role in the reduction of tolerance and dependence induced by morphine.