ABSTRACT
Background: gonadotropin-releasing hormone [GnRH] plays essential roles in embryo implantation, invasion of trophoblastic tissue, and steroid synthesis in the placenta
Objective: the aim of this study was to evaluate the effect of GnRH antagonist administration on pregnancy outcomes in early implantation period
Materials and Methods: in this retrospective study, 94 infertile women undergoing GnRH antagonist protocol who were at risk of ovarian hyperstimulation syndrome [OHSS] were included. Sixty-seven patients [group I] received Cetrorelix 0.25 mg/daily in the luteal phase for 3 days while in 27 participants [group II], it was not administered. Pregnancy outcomes were assessed based on chemical and clinical pregnancy rates
Results: the pregnancy outcomes were not significantly different between two groups [p=0.224]
Conclusion: the present study proposed that luteal phase GnRH antagonist administration does not influence the chance of successful pregnancy outcomes