ABSTRACT
Aims: Recent studies have shown independently inter-correlations between allergy, obesity, leptin hormone, and stress markers. However, these findings were unclear and contradictory. Thus the aim of the present study is to evaluate diurnal levels of salivary cortisol and DHEA in sample of Jordanian young men with history of olive pollen-induced allergic rhinitis in relation to serum levels of leptin. Methodology: 130 university male students aged (21.98±1.78) years, were divided into two groups (59 allergic and 71 non allergic). Fasting blood samples were collected and tested for blood glucose, lipid profile, serum leptin, and salivary stress hormones (cortisol and DHEA). Results: Allergic subjects showed significantly higher means of serum leptin (p<0.0001), LDL (p<0.0001), Total cholesterol (p=0.001), and BMI (p= 0.004). Also BMI and Body weight significantly correlated with serum leptin in all subjects of the study. Stronger correlation was observed in allergic subjects (r = 0.650; r = 0.589) compared with non allergic subjects (r = 0.349; r = 0.383) respectively. Simple linear regression analysis showed that morning salivary cortisol ( p=0.006) and midnight salivary DHEA ( p=0.015 ), were significantly correlated in allergic subjects with the serum leptin levels concentration. Conclusion: These results revealed an association between the morning salivary cortisol and elevated serum leptin levels in Jordanian young men with olive pollen induced allergic rhinitis.
ABSTRACT
This study ascertained the effects of soy, in the forms of textured soy protein [TSP] and soy nuts, on lipid profiles, apolipoproteins, inflammatory and prothrombotic markers, and blood pressure in elderly women diagnosed with metabolic syndrome [MetS]. This was a 12-week parallel, randomized, controlled trial conducted in rural health centers of Babol, Iran. Participants were 75 women, ages 60-70 years, who were diagnosed with MetS. Subjects were randomized to one of the following 3 groups: i] soy nut [35g/d], ii] TSP [35g/d], and iii] control. Blood biochemical markers measured at baseline and at the end of the study included: triglycerides [TG], cholesterol, HDL-C, LDL-C, VLDL-C, ApoB100, ApoAI, C-reactive protein [CRP], and fibrinogen. Soy nuts significantly improved LDL-C, VLDL-C, and ApoB100levels [P < 0.05], while fewer, significant improvements were observed in these variables in the TSP group compared to mean changes from baseline [P < 0.001]. Similar results were found for ApoAI in the treatment groups [P < 0.01]. Serum total cholesterol [TC] decreased significantly in the treatment groups compared with the control group [P < 0.005]. Differences from the control group in terms of TG, HDL-C, fibrinogen, CRP, and blood pressure were not significant. Both forms of soy improved lipid profiles. The group that consumed soy nuts had greater improvement than the TSP group. Therefore, moderate daily intake of soy may be a safe, inexpensive, and practical method to improve the risk of cardiovascular disease [CVD] and reduce the need for medical treatment
ABSTRACT
To ascertain the effects of soy [in the forms of Textured Soy Protein [TSP] and soy-nut] on lipid profiles, apolipoproteins, inflammatory and prothrombotic markers and blood pressure in elderly women with the metabolic syndrome. The study is a 12-week parallel randomized controlled trial that was conducted in rural health centres of Babol, Iran. The participants were 75 women 60-70 years old with the metabolic syndrome who were randomized to one of the three groups of soy-nut [35g/d], TSP [35g/d] and control. Blood pressure and blood biochemical markers were measured at baseline and at the end of the study including, triglyceride, cholesterol, HDL-C, LDL-C, VLDL-C, ApoB100, ApoAI, CRP and fibrinogen. The soy-nut improved significantly LDL-C, VLDL-C and Apo B100 [P<0.05] while fewer improvements but significant were observed in these variables in the TSP group only when compared with the mean changes from the baseline [P<0.001]. Similar result was found for Apo AI in the treatment groups [P<0.01]. Serum total cholesterol decreased significantly in the treatment groups compared with control group [P<0.005]. The differences from control for triglyceride, HDL-C, fibrinogen, CRP and blood pressure were not significant. Both forms of soy while improved lipids profiles the soy-nut contribution was more to this improvement than the TSP. Therefore, moderate daily intake of soy may be a safe, cheap and practical method to improve cardiovascular disease risk and also reduce the need for medical treatment