Systematic review and Meta-analysis of efficacy and safety of Xiangsha Yangwei Pills in treatment of chronic gastritis / 中国中药杂志

To systematically evaluate the efficacy and safety of Xiangsha Yangwei Pills in the treatment of chronic gastritis. Compu-ter retrieval was performed for Cochrane Library, Medline, EMbase, China Knowledge Network Database(CNKI), China Biomedical Literature Service System(SinoMed), Chongqing Weipu Chinese Science and Technology Journal Database(VIP) and WanFang Database(WanFang) randomized controlled trials about Xiangsha Yangwei Pills combined with Western medicine in the treatment of chro-nic gastritis. The retrieval time ranged from the establishment of the library to April 26, 2019. Meta-analysis was performed by RevMan 5.3 software after two independent researchers conducted literature screening, data extraction and quality evaluation according to inclusion and exclusion criteria. A total of 1 720 patients were enrolled in 18 RCT. According to the classification of chronic gastritis, they were divided into three subgroups: chronic gastritis, chronic atrophic gastritis and chronic superficial gastritis. The results of Meta-ana-lysis showed that the efficacy of Xiangsha Yangwei Pills combined with Western medicine in treating chronic gastritis was higher than that of Western medicine. As for the recurrence rate, Xiangsha Yangwei Pills combined with Western medicine was lower than Western medicine. And there was no statistical difference about helicobacter pylori(Hp) eradication rate between Xiangsha Yangwei Pills combined with Western medicine as well as Western medicine. In terms of the incidence of adverse reactions, Xiangsha Yangwei Pills combined with Western medicine was lower than Western medicine, and no serious adverse reaction was reported. The results of this systematic review showed that compared with the conventional Western medicine group, Xiangsha Yangwei Pills combined with Western medicine can significantly alleviate clinical symptoms of chronic gastritis, with fewer adverse reactions. However, due to the low methodological quality of the included studies and the reliability of the impact conclusions, high-quality multi-center, large-sample, randomized, double-blind controlled trials are needed for validation.

Effects of exercise in thermal climates on human renal function and its mechanism of oxidative stress / 解放军医学杂志

Objective: To investigate the effect of exercise in thermal climates on the renal functions and explore the role of oxidative stress injury in the pathogenesis of exertional heat stroke (EHS). Methods: Totally 187 young soldiers in the subtropical area of Southeast China were divided randomly into two groups. All subjects underwent 1.5km, 3km and 5km cross-country running under two different environmental conditions: normal temperature and normal humidity [temperature (26 ± 2) °C, humidity 50% ± 5%]; high temperature and high humidity [temperature (33 ± 2) °C, humidity 65% ± 5%], and each soldiers' blood samples were taken at pre and post running. The level of Cr, BUN, CK, CK-MB, LDH and SOD were measured by automatic biochemical analyzer. The levels of serum 8-OHdG was detected by enzyme-linked immunosorbent assay (ELISA). Results: 1) After exercise, the Cr and BUN of the two groups increased, compared with the pre-exercise the differences were significant (P<0.05). As the amount of exercise increase, the level of Cr and BUN will be further elevated, and compared with 1.5 km cross-country running respectively, there were significant differences in 3.0 km and 5.0 km cross-country running (P<0.05). The level of Cr and BUN were significantly higher in the high-temperature and high-humidity group than those in the normal temperature and normal humidity group (P<0.05); 2) After exercise, the CK, CK-MB and LDH of the two groups increased, compared with the pre-exercise the differences were significant (P<0.05). As the amount of exercise increase, the level of CK, CK-MB and LDH will be further elevated, and compared with 1.5 km cross-country running respectively, there were significant differences in 3.0 km and 5.0 km cross-country running (P<0.05). After 5.0 km cross-country running, the level of Cr and BUN were significantly higher in the high-temperature and high-humidity group than those in the normal temperature and normal humidity group (P<0.05); 3) After exercise, the level of 8-OHdG increased and the level of SOD decreased in the two groups, compared with the pre-exercise the differences were significant (P<0.05). As the amount of exercise increase, the level of 8-OHdG increased significantly and the level of SOD decreased significantly, and compared with 1.5 km cross-country running respectively, there were significant differences in 3.0 km and 5.0 km cross-country running (P<0.05). After 5.0 km cross-country running, the level of 8-OHdG were significantly higher and the level of SOD were significantly lower in the high-temperature and high-humidity group than those in the normal temperature and normal humidity group (P<0.05). Conclusion: Long time strenuous exercise under the condition of high temperature and high humidity can easily induce heat stress damage. The muscle and renal are vulnerable to heat stress damage. Oxidative stress injury may play an important role in heat stress damage of renal.