Artificial intelligence-based drug development: current progress and future challenges / 中国药科大学学报

@#In recent years, artificial intelligence (AI) has been widely applied in the field of drug discovery and development.In particular, natural language processing technology has been significantly improved after the emergence of the pre-training model.On this basis, the introduction of graph neural network has also made drug development more accurate and efficient.In order to help drug developers more systematically and comprehensively understand the application of artificial intelligence in drug discovery, this article introduces cutting-edge algorithms in AI, and elaborates on the various applications of AI in drug development, including drug small molecule design, virtual screening, drug repurposing, and drug property prediction, finally discusses the opportunities and challenges of AI in future drug development.

Clinical study of artificial dermis combined with autologous thin skin graft for repairing soft tissue wounds at joints / 重庆医学

Objective To investigate the efficacy and prognosis of artificial dermis combined with autologous skin graft in the body joints dermal wounds.Methods Twenty-five cases were collected from 2008 to 2013,who used artificial dermis combined with autologous skin graft repair articular wounds,including 10 cases of wound knee,5 cases of the ankle,4 cases of the elbow,2 cases of the wrist,3 cases of the knuckles,1 case of the axillary.Skin graft survival after surgery,the extent and functional recovery of scar formation after 3 months were observed.Results Among the patients,who underwent artificial dermis combined with autologous skin graft repair operations,dermal tissue of 1 8 cases formed well by timely removal of pus after phase one surgery.Three cases suffered artificial dermis infection,and the dermal tissue formed again after the clean dressing and drainage of pus.Two cases with severe infection underwent surgical debridement and replacement of artificial dermis,and the same treatment effect was achieved. After skin graft of phase two,autologous skin lives well.Wound area of 2 cases is small,with striping of artificial dermis film,the wound covered by the surrounding normal epithelium,and healed themselves.It shows good recovery of function in patients after 3 months follow-up,and no formation of obvious scar and scar contracture.Conclusion Artificial dermis combined with autologous skin graft therapy can not only improve the survival rates of autologous skin graft,but reduces the degree of scar contracture of joints and the long-term function recovery,and it provides an effective treatment program for tissue wounds.