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Diagnosis and treatment of Hill-Sachs combined with Bankart lesions in anterior dislocation of shoulder joint is a major clinical challenge in orthopedics, because it likely leads to a high recurrence rate of redislocation of shoulder joint, a serious damage to the shoulder joint, recurrent shoulder injury and dramatically disturbed quality of daily life. Although various means of clinical diagnosis and treatment are available for the lesions, they all have their own advantages and disadvantages. However, arthroscopic surgery of shoulder has achieved superior curative effects, gradually becoming the first choice and a mainstream treatment. This article reviews the current research progress in pathogenesis, diagnosis and arthroscopic treatment of Hill-Sachs combined with Bankart lesions in anterior dislocation of shoulder joint.
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Abstract@#On the basis of combing the working mechanism of infectious disease prevention and control in French, British and American primary and secondary schools, this paper summarizes the typical models, specific practices and the enlightenment to carry out school infectious disease prevention and control work in China. In view of the problems existing in school health and infectious disease prevention and control work, it proposes to strengthen the relevant legislation on prevention and control of public health emergencies in schools, and to clarify the countermeasures and applicable conditions in each stage of the epidemic development; to establish and improve school public health system top-level design, and to bring school health into the key area of national public health system construction; what s more the school public health professional and technical personnel training, access, employment, treatment, evaluation and incentive should be improved.
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BACKGROUND: Early prevention of hip fracture can effectively reduce the risk of hip fracture in a high-risk population. Epidemiological studies can provide guidance for the clinical prevention and treatment of such patients. OBJECTIVE: To retrospectively analyze the epidemiological distribution characteristics of patients with hip fracture admitted to the Second Hospital of Shanxi Medical University from January 1, 2016 to December 31, 2018. METHODS: To collect the patient’s age, sex, fracture type, territorial, season for injury, causes, surgical procedure, intraoperative situation, blood clots, length of hospital stay, cost, and admission to operation time, body mass index, complications, SPSS 26.0 software was used for data processing to analyze the epidemiology of hip fracture distribution characteristics in 2342 patients. RESULTS AND CONCLUSION: The average age of patients with hip fracture was (73.90±13.43) years, and hip fracture mostly occurred in the 80-90 group, accounting for 29.97%. Hip fractures were common in winter, and there was a significant difference in the seasonal distribution of femoral neck and intertrochanteric fractures. Falls resulted in the most hip fractures, accounting for 88.13%. Among the 2 108 patients with hip fractures who underwent surgical treatment, hip replacement was the major choice for femoral neck fractures, accounting for 60.03%; intramedullary fixation was the main choice for intertrochanteric fractures, accounting for 92.04%. Among the 2097 patients with hip fracture who underwent color Doppler ultrasonography, 32.38% (679/2 097) of the patients had arteriovenous thrombosis of the lower extremities, and 28.71% (195/679) of the patients had inferior vena cava filter implantation. The average hospitalization time of patients with hip fracture was (10.49±7.06) days, and the average hospitalization cost was (4.63±3.14) thousand yuan. The average hospitalization cost, average blood loss and average operation time of femoral neck fractures were significantly less than those of intertrochanteric fractures. Patients with intertrochanteric fractures were generally thinner than those with femoral neck fractures. The 44.41% of patients with hip fracture had cardiovascular and cerebrovascular diseases. These results indicate that hip fractures are mainly developed in the older adults, especially in elderly women. With the increase of age, the proportion of intertrochanteric fractures increases gradually. Falls are the main cause of hip fractures in the older adults. Surgical treatment is the main choice for hip fracture. Preoperative blood preparation and perioperative thrombosis prevention can improve the prognosis of patients.
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Abstract@#To deeply implement important instructions given by General Secretary Xi Jinping on childhood myopia prevention and control, eight departments including the Ministry of Education jointly issued the implementation. This editorial summarized current progress in preventing and controlling myopia in children and adolescents in organizational leadership, key performance indicators, team building, professional support, scientific research, financial input, publicity and education, standardized management of myopia, as well as supervision and evaluation, all of which provided important support for the building of a healthy China.
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Abstract@#To thoroughly implement General Secretary Xi Jinping’s important instructions on preventing and controlling myopia in children, the Ministry of Education together in collaboration with relevant eight departments jointly issued and implemented a plan to tackle and prevent myopia among children and young students. This article focuses on strengthening organizational leadership, optimizing system design, ensuring responsibilities of implerentation, uniting prevention and control efforts, highlighting pilot drive, strengthening demonstration guidance, promoting integration of teaching and medicine, playing the role of experts, insisting on scientific prevention and control, regularly monitoring and early warning, and reducing academic burden. Strengthen physical training, strengthen hardware construction, improve the visual environment, collaborative family-school relationship, comprehensively overcome difficulties, strengthen market supervision, standardize industry behavior, strengthen team building, strengthen professional training, support professional construction, provide intellectual support, increase financial investment, ensure the implementation of funds, strengthen publicity and education, highlight the function of educating people, improve the assessment mechanism, and be accountable according to regulations and laws. This paper summarizes the phased progress made in the comprehensive prevention and control of myopia among children and adolescents in provinces (cities, districts) across China over the past year through the solid implementation of the Plan. A number of phased achievements have been achieved, providing important supports for the construction of a healthy China.
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Objective To study the anti-tumor activity of quercetin in NB4 leukemia cells and the roles of PI3K/Akt,bcl-2,and Bax on the quercetin-induced apoptosis,and to investigate the potential underlying mechanism.Methods MTT assay was used to monitor cell proliferation,Hoechst 33258 fluorescent staining and flow cytometry were employed to detect apoptosis in NB4 cells.Western blot was used to detect the expression changes of related proteins in quercetin treated NB4 cells.Confocal laser microscopy was used to test the distributional variation of Akt between cytoplasm and nucleus.Results Quercetin significantly inhibited the NB4 cell proliferation in a dose-and time-dependent manner (20-160 μ mol/L).In addition,treated by 20,40 80 μmol/L quercetin,the rates of apoptosis were (9.25±0.11) ％,(20.83±2.10) ％and (41.43±2.90) ％,there were statistical difference compared with blank cells (t were 4.14,6.56 and 7.02,all P ＜ 0.05).This was concentration dependent and accompanied by morphological changes characteristic of apoptosis.Further,quercetin induced a G~M arrest,which might account for its cytotoxic effects.Quercetin decreased PI3k/Akt expression and caused an inhibition of the anti-apoptotic protein bcl-2,while increasing the expression of Bax.Quercetin had no effects on total Akt,but it promoted Akt translocation from cell nucleus to the cytoplasm (F =15.12,P ＜ 0.05).Conclusion Quercetin induces the leukemia NB4 cell apoptosis by affecting multiple signal pathways and plays a strong anti-leukemia effect.In addition,our results suggest that PI3K/Akt pathway could be a novel target for the leukemia chemotherapy.