ABSTRACT
<p><b>OBJECTIVE</b>To explore the risk factors of human parvovirus B19 infection in pregnancy and to provide guidelines for its prevention and control strategy.</p><p><b>METHODS</b>Four hundred and eighty-six cases of gravida serum were detected for parvovirus B19 DNA by nested-polymerase chain reaction assay. Factors associated with parvovirus B19 infection in pregnancy were investigated and analyzed, using multiple logistic regression and factor analysis.</p><p><b>RESULTS</b>Multiple logistic regression analysis suggested that there were 16 agents associated with parvovirus B19 infection during pregnancy, which were dominated by 6 potential factors listed as follows: countryside and bad hygienic habit, mental factor, occupational exposure to hospital and environmental condition, health and illness, bad behavior and health education and blood type.</p><p><b>CONCLUSION</b>The prevention strategy of parvovirus B19 infection in pregnancy should include reasonable allocation of public health resources between city and countryside, and to promote health education and occupational health during pregnancy.</p>